Identificación y análisis in silico de la dinámica plasmídica y filogenética en Borrelia s.l.

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2024
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Universidad de Caldas
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Repositorio Institucional U. Caldas
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eng
spa
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oai:repositorio.ucaldas.edu.co:ucaldas/19754
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https://repositorio.ucaldas.edu.co/handle/ucaldas/19754
https://repositorio.ucaldas.edu.co/
Palabra clave:
Borrelia s.l.
Enfermedades transmitidas por vectores,
Genomas
Plásmidos
Predicción
Análisis filogenético
Biología
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id REPOUCALDA_0f3abcd1f15106438e721c7e4ff1d986
oai_identifier_str oai:repositorio.ucaldas.edu.co:ucaldas/19754
network_acronym_str REPOUCALDA
network_name_str Repositorio Institucional U. Caldas
repository_id_str
dc.title.none.fl_str_mv Identificación y análisis in silico de la dinámica plasmídica y filogenética en Borrelia s.l.
title Identificación y análisis in silico de la dinámica plasmídica y filogenética en Borrelia s.l.
spellingShingle Identificación y análisis in silico de la dinámica plasmídica y filogenética en Borrelia s.l.
Borrelia s.l.
Enfermedades transmitidas por vectores,
Genomas
Plásmidos
Predicción
Análisis filogenético
Biología
title_short Identificación y análisis in silico de la dinámica plasmídica y filogenética en Borrelia s.l.
title_full Identificación y análisis in silico de la dinámica plasmídica y filogenética en Borrelia s.l.
title_fullStr Identificación y análisis in silico de la dinámica plasmídica y filogenética en Borrelia s.l.
title_full_unstemmed Identificación y análisis in silico de la dinámica plasmídica y filogenética en Borrelia s.l.
title_sort Identificación y análisis in silico de la dinámica plasmídica y filogenética en Borrelia s.l.
dc.contributor.none.fl_str_mv Rodríguez-Rey, Ghennie T
dc.subject.none.fl_str_mv Borrelia s.l.
Enfermedades transmitidas por vectores,
Genomas
Plásmidos
Predicción
Análisis filogenético
Biología
topic Borrelia s.l.
Enfermedades transmitidas por vectores,
Genomas
Plásmidos
Predicción
Análisis filogenético
Biología
description Gráficas
publishDate 2024
dc.date.none.fl_str_mv 2024-01-22T20:44:36Z
2024-01-22T20:44:36Z
2024-01-22
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
http://purl.org/coar/resource_type/c_7a1f
Text
info:eu-repo/semantics/bachelorThesis
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.identifier.none.fl_str_mv https://repositorio.ucaldas.edu.co/handle/ucaldas/19754
Universidad de Caldas
Repositorio Institucional Universidad de Caldas
https://repositorio.ucaldas.edu.co/
url https://repositorio.ucaldas.edu.co/handle/ucaldas/19754
https://repositorio.ucaldas.edu.co/
identifier_str_mv Universidad de Caldas
Repositorio Institucional Universidad de Caldas
dc.language.none.fl_str_mv eng
spa
language eng
spa
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dc.publisher.none.fl_str_mv Facultad de Ciencias Exactas y Naturales
Manizales
Biología
publisher.none.fl_str_mv Facultad de Ciencias Exactas y Naturales
Manizales
Biología
institution Universidad de Caldas
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spelling Identificación y análisis in silico de la dinámica plasmídica y filogenética en Borrelia s.l.Borrelia s.l.Enfermedades transmitidas por vectores,GenomasPlásmidosPredicciónAnálisis filogenéticoBiologíaGráficasEn la actualidad, las enfermedades transmitidas por vectores presentan especial atención por su aumento en la incidencia y tasa de infección en animales y humanos. Entre estas enfermedades, las causadas por bacterias patógenas del género Borrelia s. l. se destacan, siendo transmitidas por vectores como garrapatas blandas, duras y piojos a reservorios como aves, reptiles y mamíferos. El objetivo de este estudio fue realizar un análisis genómico, con el fin de predecir e identificar plásmidos con relevancia por su diversidad funcional, virulencia y resistencia antibiótica. Así mismo, se llevó a cabo una reconstrucción filogenética a partir de tres marcadores moleculares (16S ARNr, gyrB y flaB) con el fin de esclarecer las relaciones entre las genoespecies. Se ensamblaron genomas de 16 especies pertenecientes al género Borrelia s. l. A partir de los contings y empleando un algoritmo de predicción e identificación plasmídica se recuperaron un total de 98 plásmidos. Dentro de estos, 27 plásmidos se destacan por su importancia funcional, 39 corresponden a nuevos reportes para las especies y se registraron 8 nuevas predicciones para el género. Finalmente, en el análisis filogenético de 45 especies se recuperó el grupo monofilético Lyme. Este estudio se suma a la comprensión de las características genómicas y plasmídicas de las especies del género Borrelia s. l., evaluando potenciales determinantes de factores de virulencia y diversidad funcional.Currently, vector-borne diseases are receiving special attention due to their increased incidence and infection rate in animals and humans. Among these diseases, those caused by pathogenic bacteria of the genus Borrelia s. l. stand out, being transmitted by vectors such as soft and hard ticks and lice to reservoirs such as birds, reptiles and mammals. The objective of this study was to perform a genomic analysis in order to predict and identify plasmids with relevance for their functional diversity, virulence and antibiotic resistance. Likewise, a phylogenetic reconstruction was carried out based on three molecular markers (16S rRNA, gyrB and flaB) in order to clarify the relationships between genospecies. Genomes of 16 species belonging to the genus Borrelia s. l. were assembled. A total of 98 plasmids were recovered from the contings using a plasmid prediction and identification algorithm. Among these, 27 plasmids stand out for their functional importance, 39 correspond to new reports for the species and 8 new predictions were recorded for the genus. Finally, in the phylogenetic analysis of 45 species, the monophyletic group Lyme was recovered. This study adds to the understanding of the genomic and plasmid characteristics of the species of the genus Borrelia s. l., evaluating potential determinants of virulence factors and functional diversity.1. Introducción / 2. Metodología / 2 Elección de genoespecies, obtención de secuencias y ensamblaje / 2.2 Predicción plasmídica en Borrelia s. l / 2.3 Análisis filogenéticos / 3. Resultados / 3 Características de los genomas ensamblados de Borrelia s. l. / 3.2 Predicción plasmídica en Borrelia s. l / 3.3 Análisis filogenético / 4. Discusión / 4 Aspectos plasmídicos / 4.2 Análisis filogenético / 5. Conclusiones y recomendaciones / 6. Anexos / Anexo 1: Plásmidos consolidados por su interés para Borrelia s. l. / 7. 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