Costs related to infusion therapy room and staff for rheumatoid arthritis in a specialized center

Objectives Rheumatoid arthritis (RA) is a systemic, autoimmune disease with a prevalence of nearly 1% worldwide. Patients become candidates for biological therapy when the disease activity continues in moderate or severe disease activity. Some of the biological medications recommended for the treatm...

Full description

Autores:
Santos-Moreno, P
Buitrago-Garcia, D
Villarreal, L
Alvis-Zakzuk, N
Carrasquilla, M
Alvis Guzman, N
Tipo de recurso:
Article of journal
Fecha de publicación:
2018
Institución:
Corporación Universidad de la Costa
Repositorio:
REDICUC - Repositorio CUC
Idioma:
eng
OAI Identifier:
oai:repositorio.cuc.edu.co:11323/4717
Acceso en línea:
https://hdl.handle.net/11323/4717
https://repositorio.cuc.edu.co/
Palabra clave:
Artritis reumatoide
Enfermedad sistémica autoinmune
Pacientes
Terapia biológica
Costos relacionados con la terapia de infusión
Rheumatoid arthritis
Systemic autoimmune disease
Patients
Biological therapy
Costs related to infusion therapy
Rights
openAccess
License
Attribution-NonCommercial-ShareAlike 4.0 International
id RCUC2_f133b0b518aa44d3f05cd42a3c4d3582
oai_identifier_str oai:repositorio.cuc.edu.co:11323/4717
network_acronym_str RCUC2
network_name_str REDICUC - Repositorio CUC
repository_id_str
dc.title.spa.fl_str_mv Costs related to infusion therapy room and staff for rheumatoid arthritis in a specialized center
dc.title.translated.spa.fl_str_mv Costos relacionados con la sala de terapia de infusión y el personal para la artritis reumatoide en un centro especializado
title Costs related to infusion therapy room and staff for rheumatoid arthritis in a specialized center
spellingShingle Costs related to infusion therapy room and staff for rheumatoid arthritis in a specialized center
Artritis reumatoide
Enfermedad sistémica autoinmune
Pacientes
Terapia biológica
Costos relacionados con la terapia de infusión
Rheumatoid arthritis
Systemic autoimmune disease
Patients
Biological therapy
Costs related to infusion therapy
title_short Costs related to infusion therapy room and staff for rheumatoid arthritis in a specialized center
title_full Costs related to infusion therapy room and staff for rheumatoid arthritis in a specialized center
title_fullStr Costs related to infusion therapy room and staff for rheumatoid arthritis in a specialized center
title_full_unstemmed Costs related to infusion therapy room and staff for rheumatoid arthritis in a specialized center
title_sort Costs related to infusion therapy room and staff for rheumatoid arthritis in a specialized center
dc.creator.fl_str_mv Santos-Moreno, P
Buitrago-Garcia, D
Villarreal, L
Alvis-Zakzuk, N
Carrasquilla, M
Alvis Guzman, N
dc.contributor.author.spa.fl_str_mv Santos-Moreno, P
Buitrago-Garcia, D
Villarreal, L
Alvis-Zakzuk, N
Carrasquilla, M
Alvis Guzman, N
dc.subject.spa.fl_str_mv Artritis reumatoide
Enfermedad sistémica autoinmune
Pacientes
Terapia biológica
Costos relacionados con la terapia de infusión
Rheumatoid arthritis
Systemic autoimmune disease
Patients
Biological therapy
Costs related to infusion therapy
topic Artritis reumatoide
Enfermedad sistémica autoinmune
Pacientes
Terapia biológica
Costos relacionados con la terapia de infusión
Rheumatoid arthritis
Systemic autoimmune disease
Patients
Biological therapy
Costs related to infusion therapy
description Objectives Rheumatoid arthritis (RA) is a systemic, autoimmune disease with a prevalence of nearly 1% worldwide. Patients become candidates for biological therapy when the disease activity continues in moderate or severe disease activity. Some of the biological medications recommended for the treatment for RA are administrated in a hospital or infusion setting center. The aim of this study was to estimate the costs related to the infusion therapy for patients with rheumatoid arthritis. Methods We retrospectively conducted a cost-descriptive analysis using a bottom-up approach. During a 12-month period, we estimated the costs of biological therapy for patients that required monitoring in an infusion room (Infliximab, Golimumab, Tocilizumab, Abatacept and Rituximab). We costed the following items: biological therapy, time spent providing care (nurse), time spent in the infusion preparation (pharmaceutical chemistry), and the materials and supplies needed for each patient in the infusion therapy. We reported the costs in US dollars using the official rate of exchange for December 2017. Results During 2017 we included 185 patients that required the administration of biological therapy in an infusion room therapy. The cost for each patient treated per year was USD$13.004 for Golimumab, USD$8736 for Tocilizumab, USD$8.227 for Abatacept, USD$5.518 for Infliximab, and USD for $4059 Rituximab. The total cost for treating all patients was $1.531.010 million US dollars. Conclusions Biological therapy represents a high cost associated to RA care. Additionally, personnel and supplies add 7% overhead costs to the therapy. Compared to other studies, our cost estimations are ten time less than studies carried out in hospitals from the United States. This micro-costing analysis is an important input for stakeholders and decision makers about the financial impact of the usage of biological therapy in patients with RA.
publishDate 2018
dc.date.issued.none.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2019-05-27T14:04:38Z
dc.date.available.none.fl_str_mv 2019-05-27T14:04:38Z
dc.type.spa.fl_str_mv Artículo de revista
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.content.spa.fl_str_mv Text
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
format http://purl.org/coar/resource_type/c_6501
status_str acceptedVersion
dc.identifier.uri.spa.fl_str_mv https://hdl.handle.net/11323/4717
dc.identifier.instname.spa.fl_str_mv Corporación Universidad de la Costa
dc.identifier.reponame.spa.fl_str_mv REDICUC - Repositorio CUC
dc.identifier.repourl.spa.fl_str_mv https://repositorio.cuc.edu.co/
url https://hdl.handle.net/11323/4717
https://repositorio.cuc.edu.co/
identifier_str_mv Corporación Universidad de la Costa
REDICUC - Repositorio CUC
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.spa.fl_str_mv https://doi.org/10.1016/j.jval.2018.04.845
dc.rights.spa.fl_str_mv Attribution-NonCommercial-ShareAlike 4.0 International
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv Attribution-NonCommercial-ShareAlike 4.0 International
http://creativecommons.org/licenses/by-nc-sa/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.publisher.spa.fl_str_mv Value in health 21
institution Corporación Universidad de la Costa
bitstream.url.fl_str_mv https://repositorio.cuc.edu.co/bitstreams/ad5ba44a-2343-4a75-9d11-712c81102836/download
https://repositorio.cuc.edu.co/bitstreams/e5f46077-fad5-422c-8063-ec7f81cd7a6f/download
https://repositorio.cuc.edu.co/bitstreams/cea82d28-5805-43d3-8302-b546322bbda0/download
https://repositorio.cuc.edu.co/bitstreams/98e7e88d-3cac-401f-a7bc-428bacb931d5/download
https://repositorio.cuc.edu.co/bitstreams/63dd4155-577c-49d4-b304-f5cf2282f9f9/download
bitstream.checksum.fl_str_mv 360d3ccb9a7d97e7015405da184646d1
934f4ca17e109e0a05eaeaba504d7ce4
8a4605be74aa9ea9d79846c1fba20a33
8de515e41581d40c0fdc123fe55fa9e5
99af0c17a5e70fc9c7345c7fa6cddfd7
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio de la Universidad de la Costa CUC
repository.mail.fl_str_mv repdigital@cuc.edu.co
_version_ 1828166833409097728
spelling Santos-Moreno, PBuitrago-Garcia, DVillarreal, LAlvis-Zakzuk, NCarrasquilla, MAlvis Guzman, N2019-05-27T14:04:38Z2019-05-27T14:04:38Z2018https://hdl.handle.net/11323/4717Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Objectives Rheumatoid arthritis (RA) is a systemic, autoimmune disease with a prevalence of nearly 1% worldwide. Patients become candidates for biological therapy when the disease activity continues in moderate or severe disease activity. Some of the biological medications recommended for the treatment for RA are administrated in a hospital or infusion setting center. The aim of this study was to estimate the costs related to the infusion therapy for patients with rheumatoid arthritis. Methods We retrospectively conducted a cost-descriptive analysis using a bottom-up approach. During a 12-month period, we estimated the costs of biological therapy for patients that required monitoring in an infusion room (Infliximab, Golimumab, Tocilizumab, Abatacept and Rituximab). We costed the following items: biological therapy, time spent providing care (nurse), time spent in the infusion preparation (pharmaceutical chemistry), and the materials and supplies needed for each patient in the infusion therapy. We reported the costs in US dollars using the official rate of exchange for December 2017. Results During 2017 we included 185 patients that required the administration of biological therapy in an infusion room therapy. The cost for each patient treated per year was USD$13.004 for Golimumab, USD$8736 for Tocilizumab, USD$8.227 for Abatacept, USD$5.518 for Infliximab, and USD for $4059 Rituximab. The total cost for treating all patients was $1.531.010 million US dollars. Conclusions Biological therapy represents a high cost associated to RA care. Additionally, personnel and supplies add 7% overhead costs to the therapy. Compared to other studies, our cost estimations are ten time less than studies carried out in hospitals from the United States. This micro-costing analysis is an important input for stakeholders and decision makers about the financial impact of the usage of biological therapy in patients with RA.Los objetivos La artritis reumatoide (AR) es una enfermedad sistémica autoinmune con una prevalencia de casi el 1% en todo el mundo. Los pacientes se vuelven candidatos para terapia biológica cuando la actividad de la enfermedad continúa en actividad de enfermedad moderada o grave. Algunos de los medicamentos biológicos recomendados para el tratamiento de la AR se administran en un hospital o centro de instalación de infusión. El objetivo de este estudio fue estimar los costos relacionados con la terapia de infusión para pacientes con artritis reumatoide. Los metodos Realizamos retrospectivamente un análisis descriptivo de los costos utilizando un enfoque de abajo hacia arriba. Durante un período de 12 meses, estimamos los costos de la terapia biológica para los pacientes que requirieron monitoreo en una sala de infusión (Infliximab, Golimumab, Tocilizumab, Abatacept y Rituximab). Hemos calculado los siguientes artículos: terapia biológica, tiempo dedicado a la atención (enfermera), tiempo dedicado a la preparación de la infusión (química farmacéutica) y los materiales y suministros necesarios para cada paciente en la terapia de infusión. Informamos los costos en dólares estadounidenses utilizando el tipo de cambio oficial de diciembre de 2017. Resultados Durante 2017, se incluyeron 185 pacientes que requirieron la administración de terapia biológica en una terapia de sala de infusión. El costo por cada paciente tratado por año fue de USD $ 13.004 para Golimumab, USD $ 8736 para Tocilizumab, USD $ 8.227 para Abatacept, USD $ 5.518 para Infliximab y USD por $ 4059 Rituximab. El costo total para el tratamiento de todos los pacientes fue de $ 1,531.010 millones de dólares estadounidenses. Conclusiones La terapia biológica representa un alto costo asociado a la atención de la AR. Además, el personal y los suministros agregan un 7% de gastos generales a la terapia. En comparación con otros estudios, nuestras estimaciones de costos son diez veces menos que los estudios realizados en hospitales de los Estados Unidos. Este análisis de costo reducido es un aporte importante para las partes interesadas y los tomadores de decisiones sobre el impacto financiero del uso de la terapia biológica en pacientes con AR.Santos-Moreno, P-4c8bf522-fd2f-4d0d-bd00-433bf39bccbf-0Buitrago-Garcia, D-f72f35bb-b832-4224-b846-95d3948c1509-0Villarreal, L-0e7db4bd-aaff-42eb-b6c7-f475dbb3fe50-0Alvis-Zakzuk, N-4ad43f03-69e9-4fe7-b60d-070645964218-0Carrasquilla, M-c777b5bf-3e08-468d-9bb7-9fdd4a8f5e28-0Alvis Guzman, N-2d13fafb-f99f-45da-90f0-c24f33bc4418-0engValue in health 21https://doi.org/10.1016/j.jval.2018.04.845Attribution-NonCommercial-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Artritis reumatoideEnfermedad sistémica autoinmunePacientesTerapia biológicaCostos relacionados con la terapia de infusiónRheumatoid arthritisSystemic autoimmune diseasePatientsBiological therapyCosts related to infusion therapyCosts related to infusion therapy room and staff for rheumatoid arthritis in a specialized centerCostos relacionados con la sala de terapia de infusión y el personal para la artritis reumatoide en un centro especializadoArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/acceptedVersionPublicationORIGINALPIIS1098301518311458.pdfPIIS1098301518311458.pdfapplication/pdf81150https://repositorio.cuc.edu.co/bitstreams/ad5ba44a-2343-4a75-9d11-712c81102836/download360d3ccb9a7d97e7015405da184646d1MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81031https://repositorio.cuc.edu.co/bitstreams/e5f46077-fad5-422c-8063-ec7f81cd7a6f/download934f4ca17e109e0a05eaeaba504d7ce4MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.cuc.edu.co/bitstreams/cea82d28-5805-43d3-8302-b546322bbda0/download8a4605be74aa9ea9d79846c1fba20a33MD53THUMBNAILPIIS1098301518311458.pdf.jpgPIIS1098301518311458.pdf.jpgimage/jpeg85050https://repositorio.cuc.edu.co/bitstreams/98e7e88d-3cac-401f-a7bc-428bacb931d5/download8de515e41581d40c0fdc123fe55fa9e5MD55TEXTPIIS1098301518311458.pdf.txtPIIS1098301518311458.pdf.txttext/plain12883https://repositorio.cuc.edu.co/bitstreams/63dd4155-577c-49d4-b304-f5cf2282f9f9/download99af0c17a5e70fc9c7345c7fa6cddfd7MD5611323/4717oai:repositorio.cuc.edu.co:11323/47172024-09-17 14:15:38.309http://creativecommons.org/licenses/by-nc-sa/4.0/Attribution-NonCommercial-ShareAlike 4.0 Internationalopen.accesshttps://repositorio.cuc.edu.coRepositorio de la Universidad de la Costa CUCrepdigital@cuc.edu.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