Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset
Ongoing assessment of patients with Alzheimer's disease (AD) in postapproval studies is important for mapping disease progression and evaluating real-world treatment effectiveness and safety. However, interpreting outcomes in the real world is challenging owing to variation in data collected ac...
- Autores:
-
Galvin, James E.
Cummings, Jeffrey L.
Levitchi Benea, Mihaela
de Moor, Carl
Allegri, Ricardo Francisco
Atri, Alireza
Chertkow, Howard
Paquet, Claire
Porter, Verna R.
Ritchie, Craig W.
Sikkes, Sietske A. M.
Smith, Michael R.
Grassi, Christina Marsica
Rubino, Ivana
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2024
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/14084
- Acceso en línea:
- https://hdl.handle.net/11323/14084
https://repositorio.cuc.edu.co/
- Palabra clave:
- Alzheimer's disease
Core outcomes
Data collection
Population
Real-world evidence
Study aims
- Rights
- openAccess
- License
- Atribución 4.0 Internacional (CC BY 4.0)
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Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset |
| title |
Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset |
| spellingShingle |
Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset Alzheimer's disease Core outcomes Data collection Population Real-world evidence Study aims |
| title_short |
Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset |
| title_full |
Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset |
| title_fullStr |
Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset |
| title_full_unstemmed |
Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset |
| title_sort |
Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset |
| dc.creator.fl_str_mv |
Galvin, James E. Cummings, Jeffrey L. Levitchi Benea, Mihaela de Moor, Carl Allegri, Ricardo Francisco Atri, Alireza Chertkow, Howard Paquet, Claire Porter, Verna R. Ritchie, Craig W. Sikkes, Sietske A. M. Smith, Michael R. Grassi, Christina Marsica Rubino, Ivana |
| dc.contributor.author.none.fl_str_mv |
Galvin, James E. Cummings, Jeffrey L. Levitchi Benea, Mihaela de Moor, Carl Allegri, Ricardo Francisco Atri, Alireza Chertkow, Howard Paquet, Claire Porter, Verna R. Ritchie, Craig W. Sikkes, Sietske A. M. Smith, Michael R. Grassi, Christina Marsica Rubino, Ivana |
| dc.subject.proposal.eng.fl_str_mv |
Alzheimer's disease Core outcomes Data collection Population Real-world evidence Study aims |
| topic |
Alzheimer's disease Core outcomes Data collection Population Real-world evidence Study aims |
| description |
Ongoing assessment of patients with Alzheimer's disease (AD) in postapproval studies is important for mapping disease progression and evaluating real-world treatment effectiveness and safety. However, interpreting outcomes in the real world is challenging owing to variation in data collected across centers and specialties and greater heterogeneity of patients compared with trial participants. Here, we share considerations for observational postapproval studies designed to collect harmonized longitudinal data from individuals with mild cognitive impairment or mild dementia stage of disease who receive therapies targeting the underlying pathological processes of AD in routine practice. This paper considers key study design parameters, including proposed aims and objectives, study populations, approaches to data collection, and measures of cognition, functional abilities, neuropsychiatric status, quality of life, health economics, safety, and drug utilization. Postapproval studies that capture these considerations will be important to provide standardized data on AD treatment effectiveness and safety in real-world settings. |
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2024 |
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2024-05-06 |
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2025-04-04T15:07:46Z |
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2025-04-04T15:07:46Z |
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Galvin JE, Cummings JL, Benea ML, et al. Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset. Alzheimer's Dement. 2024; 20: 4331–4341. https://doi.org/10.1002/alz.13785 |
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1552-5260 |
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https://hdl.handle.net/11323/14084 |
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10.1002/alz.13785 |
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1552-5279 |
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Corporación Universidad de la Costa |
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REDICUC - Repositorio CUC |
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https://repositorio.cuc.edu.co/ |
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Galvin JE, Cummings JL, Benea ML, et al. Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset. Alzheimer's Dement. 2024; 20: 4331–4341. https://doi.org/10.1002/alz.13785 1552-5260 10.1002/alz.13785 1552-5279 Corporación Universidad de la Costa REDICUC - Repositorio CUC |
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https://hdl.handle.net/11323/14084 https://repositorio.cuc.edu.co/ |
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eng |
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eng |
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Alzheimer's and Dementia |
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Nazha B, Yang JC-H, Owonikoko TK. Benefits and limitations of real-world evidence: lessons from EGFR mutation-positive non-small-cell lung cancer. Future Oncol. 2021; 17: 965-977. doi:10.2217/fon-2020-0951 U.S. Food & Drug Administration (FDA). Framework for FDA's real-world evidence program 2018. (accessed March 8, 2022). https://www.fda.gov/media/120060/download U.S. Food & Drug Administration (FDA). Real-world evidence 2022. (accessed January 27, 2023). https://www.fda.gov/science-research/science-and-research-special-topics/real-world-evidence Bonamici S. H.R.34—114th Congress (2015-2016): 21st Century Cures Act 2016. (accessed March 22, 2023). https://www.congress.gov/bill/114th-congress/house-bill/34/ U.S. Food & Drug Administration (FDA). ADUHELM: highlights of prescribing information (PI) 2023. (accessed March 19, 2023). https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/761178s007lbl.pdf U.S. Food & Drug Administration (FDA). LEQEMBI: highlights of prescribing information (PI) 2023. (accessed October 5, 2023). https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/761269Orig1s001lbl.pdf Alzheimer's Network for Treatment and Diagnostics. ALZ-NET 2023. (accessed March 19, 2023). https://www.alz-net.org/ European Medicines Agency (EMA). Guideline on registry-based studies 2020. (accessed October 16, 2020). https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-registry-based-studies_en.pdf Centers for Medicare and Medicaid Services (CMS). Prospective study on anti-amyloid-β monoclonal antibodies directed against amyloid for the treatment of Alzheimer's disease coverage of evidence development (the Anti-aβ mAb CED study) 2023. (accessed October 5, 2023). https://www.cms.gov/files/document/ced-study-description.pdf Yang W, Zilov A, Soewondo P, Bech OM, Sekkal F, Home PD. Observational studies: going beyond the boundaries of randomized controlled trials. Diabetes Res Clin Pract. 2010; 88(1): S3-S9. doi:10.1016/S0168-8227(10)70002-4 Ismail RK, Sikkes NO, Wouters MW, et al. Postapproval trials versus patient registries: comparability of advanced melanoma patients with brain metastases. Melanoma Res. 2021; 31: 58-66. doi:10.1097/CMR.0000000000000707 U.S. Food & Drug Administration (FDA). FDA converts novel Alzheimer's disease treatment to traditional approval 2023. (accessed October 5, 2023). https://www.fda.gov/news-events/press-announcements/fda-converts-novel-alzheimers-disease-treatment-traditional-approval U.S. Food & Drug Administration (FDA). FDA grants accelerated approval for Alzheimer's drug 2021. (accessed October 5, 2023). https://www.fda.gov/news-events/press-announcements/fda-grants-accelerated-approval-alzheimers-drug Cummings J, Rabinovici GD, Atri A, et al. Aducanumab: Appropriate Use Recommendations update. J Prev Alzheimers Dis. 2022; 9: 221-230. doi:10.14283/jpad.2022.34 Cummings J, Apostolova L, Rabinovici GD, et al. Lecanemab: Appropriate Use Recommendations. J Prev Alzheimers Dis. 2023; 10: 362-377. doi:10.14283/jpad.2023.30 Spieth PM, Kubasch AS, Penzlin AI, Illigens BM-W, Barlinn K, Siepmann T. Randomized controlled trials—a matter of design. Neuropsychiatr Dis Treat. 2016; 12: 1341-1349. doi:10.2147/NDT.S101938 Depp C, Lebowitz BD. Clinical trials: bridging the gap between efficacy and effectiveness. Int Rev Psychiatry. 2007; 19: 531-539. doi:10.1080/09540260701563320 Atri A, Rountree SD, Lopez OL, Doody RS. Validity, significance, strengths, limitations, and evidentiary value of real-world clinical data for combination therapy in Alzheimer's disease: comparison of efficacy and effectiveness studies. Neurodegener Dis. 2012; 10: 170-174. doi:10.1159/000335156 Banzi R, Camaioni P, Tettamanti M, Bertele’ V, Lucca U. Older patients are still under-represented in clinical trials of Alzheimer's disease. Alzheimers Res Ther. 2016; 8: 32. doi:10.1186/s13195-016-0201-2 Mitchell AK, Massett HA, Shakur M, Lockett J, Han SH. Analysis of exclusion criteria in NIA-funded Alzheimer's disease and Alzheimer's disease-related dementias clinical trials. Alzheimers Dement. 2021; 17(10):e054416. doi:10.1002/alz.054416 |
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© 2024 The Authors. |
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Atribución 4.0 Internacional (CC BY 4.0) |
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Atribución 4.0 Internacional (CC BY 4.0)© 2024 The Authors.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Galvin, James E.Cummings, Jeffrey L.Levitchi Benea, Mihaelade Moor, CarlAllegri, Ricardo Franciscovirtual::1007-1Atri, AlirezaChertkow, HowardPaquet, ClairePorter, Verna R.Ritchie, Craig W.Sikkes, Sietske A. M.Smith, Michael R.Grassi, Christina MarsicaRubino, Ivana2025-04-04T15:07:46Z2025-04-04T15:07:46Z2024-05-06Galvin JE, Cummings JL, Benea ML, et al. Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset. Alzheimer's Dement. 2024; 20: 4331–4341. https://doi.org/10.1002/alz.137851552-5260https://hdl.handle.net/11323/1408410.1002/alz.137851552-5279Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Ongoing assessment of patients with Alzheimer's disease (AD) in postapproval studies is important for mapping disease progression and evaluating real-world treatment effectiveness and safety. However, interpreting outcomes in the real world is challenging owing to variation in data collected across centers and specialties and greater heterogeneity of patients compared with trial participants. Here, we share considerations for observational postapproval studies designed to collect harmonized longitudinal data from individuals with mild cognitive impairment or mild dementia stage of disease who receive therapies targeting the underlying pathological processes of AD in routine practice. This paper considers key study design parameters, including proposed aims and objectives, study populations, approaches to data collection, and measures of cognition, functional abilities, neuropsychiatric status, quality of life, health economics, safety, and drug utilization. Postapproval studies that capture these considerations will be important to provide standardized data on AD treatment effectiveness and safety in real-world settings.11 páginasapplication/pdfengJohn Wiley & Sons Inc.United Stateshttps://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.13785Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core datasetArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Alzheimer's and DementiaNazha B, Yang JC-H, Owonikoko TK. Benefits and limitations of real-world evidence: lessons from EGFR mutation-positive non-small-cell lung cancer. Future Oncol. 2021; 17: 965-977. doi:10.2217/fon-2020-0951U.S. Food & Drug Administration (FDA). Framework for FDA's real-world evidence program 2018. (accessed March 8, 2022). https://www.fda.gov/media/120060/downloadU.S. Food & Drug Administration (FDA). Real-world evidence 2022. (accessed January 27, 2023). https://www.fda.gov/science-research/science-and-research-special-topics/real-world-evidenceBonamici S. H.R.34—114th Congress (2015-2016): 21st Century Cures Act 2016. (accessed March 22, 2023). https://www.congress.gov/bill/114th-congress/house-bill/34/U.S. Food & Drug Administration (FDA). ADUHELM: highlights of prescribing information (PI) 2023. (accessed March 19, 2023). https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/761178s007lbl.pdfU.S. Food & Drug Administration (FDA). LEQEMBI: highlights of prescribing information (PI) 2023. (accessed October 5, 2023). https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/761269Orig1s001lbl.pdfAlzheimer's Network for Treatment and Diagnostics. ALZ-NET 2023. (accessed March 19, 2023). https://www.alz-net.org/European Medicines Agency (EMA). Guideline on registry-based studies 2020. (accessed October 16, 2020). https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-registry-based-studies_en.pdfCenters for Medicare and Medicaid Services (CMS). Prospective study on anti-amyloid-β monoclonal antibodies directed against amyloid for the treatment of Alzheimer's disease coverage of evidence development (the Anti-aβ mAb CED study) 2023. (accessed October 5, 2023). https://www.cms.gov/files/document/ced-study-description.pdfYang W, Zilov A, Soewondo P, Bech OM, Sekkal F, Home PD. Observational studies: going beyond the boundaries of randomized controlled trials. Diabetes Res Clin Pract. 2010; 88(1): S3-S9. doi:10.1016/S0168-8227(10)70002-4Ismail RK, Sikkes NO, Wouters MW, et al. Postapproval trials versus patient registries: comparability of advanced melanoma patients with brain metastases. Melanoma Res. 2021; 31: 58-66. doi:10.1097/CMR.0000000000000707U.S. Food & Drug Administration (FDA). FDA converts novel Alzheimer's disease treatment to traditional approval 2023. (accessed October 5, 2023). https://www.fda.gov/news-events/press-announcements/fda-converts-novel-alzheimers-disease-treatment-traditional-approvalU.S. Food & Drug Administration (FDA). FDA grants accelerated approval for Alzheimer's drug 2021. (accessed October 5, 2023). https://www.fda.gov/news-events/press-announcements/fda-grants-accelerated-approval-alzheimers-drugCummings J, Rabinovici GD, Atri A, et al. Aducanumab: Appropriate Use Recommendations update. J Prev Alzheimers Dis. 2022; 9: 221-230. doi:10.14283/jpad.2022.34Cummings J, Apostolova L, Rabinovici GD, et al. Lecanemab: Appropriate Use Recommendations. J Prev Alzheimers Dis. 2023; 10: 362-377. doi:10.14283/jpad.2023.30Spieth PM, Kubasch AS, Penzlin AI, Illigens BM-W, Barlinn K, Siepmann T. Randomized controlled trials—a matter of design. Neuropsychiatr Dis Treat. 2016; 12: 1341-1349. doi:10.2147/NDT.S101938Depp C, Lebowitz BD. Clinical trials: bridging the gap between efficacy and effectiveness. Int Rev Psychiatry. 2007; 19: 531-539. doi:10.1080/09540260701563320Atri A, Rountree SD, Lopez OL, Doody RS. Validity, significance, strengths, limitations, and evidentiary value of real-world clinical data for combination therapy in Alzheimer's disease: comparison of efficacy and effectiveness studies. Neurodegener Dis. 2012; 10: 170-174. doi:10.1159/000335156Banzi R, Camaioni P, Tettamanti M, Bertele’ V, Lucca U. Older patients are still under-represented in clinical trials of Alzheimer's disease. Alzheimers Res Ther. 2016; 8: 32. doi:10.1186/s13195-016-0201-2Mitchell AK, Massett HA, Shakur M, Lockett J, Han SH. Analysis of exclusion criteria in NIA-funded Alzheimer's disease and Alzheimer's disease-related dementias clinical trials. Alzheimers Dement. 2021; 17(10):e054416. doi:10.1002/alz.05441643414331620Alzheimer's diseaseCore outcomesData collectionPopulationReal-world evidenceStudy aimsPublication3a5e2fdd-48ee-4d8e-acc4-3119bbdc1a17virtual::1007-13a5e2fdd-48ee-4d8e-acc4-3119bbdc1a17virtual::1007-1https://scholar.google.com/citations?user=-SIKk2UAAAAJ&hl=esvirtual::1007-10000-0001-7166-1234virtual::1007-1ORIGINALAlzheimer s Dementia - 2024 - Galvin - Generating real‐world evidence in Alzheimer s disease Considerations for.pdfAlzheimer s Dementia - 2024 - Galvin - Generating real‐world evidence in Alzheimer s disease Considerations for.pdfapplication/pdf554705https://repositorio.cuc.edu.co/bitstreams/e0f90d3e-ee06-4012-8534-7fe56b8fb317/downloadb3fd70f4ec51f18a7c4c820d3581026aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-815543https://repositorio.cuc.edu.co/bitstreams/86d2bc70-c9cb-4292-8f39-892194334fa4/download73a5432e0b76442b22b026844140d683MD52TEXTAlzheimer s Dementia - 2024 - Galvin - Generating 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ara ejercer estos derechos sobre la Obra tal y como se indica a continuación:</p>
    <ol type="a">
      <li>Reproducir la Obra, incorporar la Obra en una o más Obras Colectivas, y reproducir la Obra incorporada en las Obras Colectivas.</li>
      <li>Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.</li>
      <li>Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.</li>
    </ol>
    <p>Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).</p>
  </li>
  <br/>
  <li>
    Restricciones.
    <p>La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:</p>
    <ol type="a">
      <li>Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).</li>
      <li>Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.</li>
      <li>Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.</li>
      <li>
        Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:
        <ol type="i">
          <li>Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.</li>
          <li>Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.</li>
        </ol>
      </li>
      <li>Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.</li>
    </ol>
  </li>
  <br/>
  <li>
    Representaciones, Garantías y Limitaciones de Responsabilidad.
    <p>A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.</p>
  </li>
  <br/>
  <li>
    Limitación de responsabilidad.
    <p>A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.</p>
  </li>
  <br/>
  <li>
    Término.
    <ol type="a">
      <li>Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.</li>
      <li>Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.</li>
    </ol>
  </li>
  <br/>
  <li>
    Varios.
    <ol type="a">
      <li>Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.</li>
      <li>Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.</li>
      <li>Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.</li>
      <li>Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.</li>
    </ol>
  </li>
  <br/>
</ol>
 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