Enzyme-mediated synthesis of Molnupiravir: paving the way for the application of biocatalysis in pharmaceutical industry
Molnupiravir (Lagevrio®) is an orally-administered anti-COVID-19 agent. Due to the urgency to meet the worldwide demand and the growing environmental concern, there is a need for speed in the industrial implementation of novel and efficient bioprocesses for Molnupiravir synthesis. This concept paper...
- Autores:
-
Guillermo Cruz, Javier Acosta
Del Arco, Jon
Clemente-Suárez, Vicente Javier
Deroncele, Víctor
Fernández-Lucas, Jesús
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2021
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/9462
- Acceso en línea:
- https://hdl.handle.net/11323/9462
https://doi.org/10.1002/cctc.202200140
https://repositorio.cuc.edu.co/
- Palabra clave:
- (Chemo) enzymatic processes
Eco-friendly
Industrial scale-up
Molnupiravir
- Rights
- embargoedAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
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| dc.title.eng.fl_str_mv |
Enzyme-mediated synthesis of Molnupiravir: paving the way for the application of biocatalysis in pharmaceutical industry |
| title |
Enzyme-mediated synthesis of Molnupiravir: paving the way for the application of biocatalysis in pharmaceutical industry |
| spellingShingle |
Enzyme-mediated synthesis of Molnupiravir: paving the way for the application of biocatalysis in pharmaceutical industry (Chemo) enzymatic processes Eco-friendly Industrial scale-up Molnupiravir |
| title_short |
Enzyme-mediated synthesis of Molnupiravir: paving the way for the application of biocatalysis in pharmaceutical industry |
| title_full |
Enzyme-mediated synthesis of Molnupiravir: paving the way for the application of biocatalysis in pharmaceutical industry |
| title_fullStr |
Enzyme-mediated synthesis of Molnupiravir: paving the way for the application of biocatalysis in pharmaceutical industry |
| title_full_unstemmed |
Enzyme-mediated synthesis of Molnupiravir: paving the way for the application of biocatalysis in pharmaceutical industry |
| title_sort |
Enzyme-mediated synthesis of Molnupiravir: paving the way for the application of biocatalysis in pharmaceutical industry |
| dc.creator.fl_str_mv |
Guillermo Cruz, Javier Acosta Del Arco, Jon Clemente-Suárez, Vicente Javier Deroncele, Víctor Fernández-Lucas, Jesús |
| dc.contributor.author.spa.fl_str_mv |
Guillermo Cruz, Javier Acosta Del Arco, Jon Clemente-Suárez, Vicente Javier Deroncele, Víctor Fernández-Lucas, Jesús |
| dc.subject.proposal.eng.fl_str_mv |
(Chemo) enzymatic processes Eco-friendly Industrial scale-up Molnupiravir |
| topic |
(Chemo) enzymatic processes Eco-friendly Industrial scale-up Molnupiravir |
| description |
Molnupiravir (Lagevrio®) is an orally-administered anti-COVID-19 agent. Due to the urgency to meet the worldwide demand and the growing environmental concern, there is a need for speed in the industrial implementation of novel and efficient bioprocesses for Molnupiravir synthesis. This concept paper aims to review the most relevant milestones that have guided important developments in the enzyme-mediated synthesis of Molnupiravir, including detailed comments on the advantages and drawbacks of the different synthetic routes. Finally, based on a personal perspective, new greener processes for Molnupiravir manufacturing are proposed and discussed. |
| publishDate |
2021 |
| dc.date.issued.none.fl_str_mv |
2021-04-28 |
| dc.date.accessioned.none.fl_str_mv |
2022-08-22T20:35:47Z |
| dc.date.available.none.fl_str_mv |
2022-08-22T20:35:47Z 2023-04-28 |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Text |
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1867-3880 |
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https://hdl.handle.net/11323/9462 |
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https://doi.org/10.1002/cctc.202200140 |
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10.1002/cctc.202200140 |
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1867-3899 |
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Corporación Universidad de la Costa |
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REDICUC - Repositorio CUC |
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https://repositorio.cuc.edu.co/ |
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1867-3880 10.1002/cctc.202200140 1867-3899 Corporación Universidad de la Costa REDICUC - Repositorio CUC |
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https://hdl.handle.net/11323/9462 https://doi.org/10.1002/cctc.202200140 https://repositorio.cuc.edu.co/ |
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eng |
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eng |
| dc.relation.ispartofjournal.spa.fl_str_mv |
ChemCatChem |
| dc.relation.citationissue.spa.fl_str_mv |
13 |
| dc.relation.citationvolume.spa.fl_str_mv |
14 |
| dc.rights.spa.fl_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) © 1999-2022 John Wiley & Sons, Inc. All rights reserved |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) © 1999-2022 John Wiley & Sons, Inc. All rights reserved https://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_f1cf |
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1 página |
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application/pdf |
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Wiley - VCH Verlag GmbH & CO. KGaA |
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Germany |
| institution |
Corporación Universidad de la Costa |
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Guillermo Cruz, Javier AcostaDel Arco, JonClemente-Suárez, Vicente JavierDeroncele, VíctorFernández-Lucas, Jesús2022-08-22T20:35:47Z2023-04-282022-08-22T20:35:47Z2021-04-281867-3880https://hdl.handle.net/11323/9462https://doi.org/10.1002/cctc.20220014010.1002/cctc.2022001401867-3899Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Molnupiravir (Lagevrio®) is an orally-administered anti-COVID-19 agent. Due to the urgency to meet the worldwide demand and the growing environmental concern, there is a need for speed in the industrial implementation of novel and efficient bioprocesses for Molnupiravir synthesis. This concept paper aims to review the most relevant milestones that have guided important developments in the enzyme-mediated synthesis of Molnupiravir, including detailed comments on the advantages and drawbacks of the different synthetic routes. 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