Exploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering

Ionic liquids (ILs) are widely used in many applications. Still, their use in enzyme engineering is particularly notable due to their environmentally friendly nature and efficient replacement of conventional organic solvents. Recently, lipase has emerged as an environmentally friendly catalyst. Neve...

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Autores:: Castro Bizerra, Viviane de
Fernandes Melo , Rafael Leandro
Sim˜ ao Neto, Francisco
de Castro, Erico Carlos
Bessa Sales, Misael
Paulo Gonçalves de Sousa Junior
Nascimento Dari, Dayana
da Silva Aires, Francisco Izaias
Moreira dos Santos, Kaiany
França Serpa, Juliana de
H. Kim, Tak
Fernandez-Lucas, Jesús
Martins de Souza, Maria Cristiane
dos Santos, Jose C.S.

Tipo de recurso:: Article of investigation

Fecha de publicación:: 2024

Institución:: Corporación Universidad de la Costa

Repositorio:: REDICUC - Repositorio CUC

Idioma:: eng

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network_acronym_str	RCUC2
network_name_str	REDICUC - Repositorio CUC
repository_id_str
dc.title.eng.fl_str_mv	Exploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering
title	Exploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering
spellingShingle	Exploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering Bibliometric analysis Enzyme engineering Ionic liquids Lipase
title_short	Exploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering
title_full	Exploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering
title_fullStr	Exploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering
title_full_unstemmed	Exploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering
title_sort	Exploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering
dc.creator.fl_str_mv	Castro Bizerra, Viviane de Fernandes Melo , Rafael Leandro Sim˜ ao Neto, Francisco de Castro, Erico Carlos Bessa Sales, Misael Paulo Gonçalves de Sousa Junior Nascimento Dari, Dayana da Silva Aires, Francisco Izaias Moreira dos Santos, Kaiany França Serpa, Juliana de H. Kim, Tak Fernandez-Lucas, Jesús Martins de Souza, Maria Cristiane dos Santos, Jose C.S.
dc.contributor.author.none.fl_str_mv	Castro Bizerra, Viviane de Fernandes Melo , Rafael Leandro Sim˜ ao Neto, Francisco de Castro, Erico Carlos Bessa Sales, Misael Paulo Gonçalves de Sousa Junior Nascimento Dari, Dayana da Silva Aires, Francisco Izaias Moreira dos Santos, Kaiany França Serpa, Juliana de H. Kim, Tak Fernandez-Lucas, Jesús Martins de Souza, Maria Cristiane dos Santos, Jose C.S.
dc.subject.proposal.eng.fl_str_mv	Bibliometric analysis Enzyme engineering Ionic liquids Lipase
topic	Bibliometric analysis Enzyme engineering Ionic liquids Lipase
description	Ionic liquids (ILs) are widely used in many applications. Still, their use in enzyme engineering is particularly notable due to their environmentally friendly nature and efficient replacement of conventional organic solvents. Recently, lipase has emerged as an environmentally friendly catalyst. Nevertheless, using Lipases in the presence of ILs has led to a remarkable activity enhancement, making it a sustainable and non-harmful approach. This study conducted a bibliometric review of research articles published between 2010 and 2022 concerning the use of ILs in lipase-catalyzed reactions. The analysis was based on 206 publications retrieved from the Web of Science Core Collection (WoS) database., which were analyzed using different software tools, such as VOSviewer, CiteSpace, and ArcGIS. Key findings included that over half of the publications originated from other countries, notably China (around 36.4%), the United States, Spain, and France. As a result of this bibliometric analysis, four emerging trends were identified: namely: i) lipase-catalyzed synthesis, ii) the use of deep eutectic solvent, iii) the application of ILs in secondary alcohol reactions, iv) the use of ILs as green solvents, and iv) the enzymatic ring-opening polymerization. The study also evaluated the most prominent authors, articles, and institutions that provide comprehensive data on up-to-date research on ILs and lipases. It is noted that the studies identify significant advantages in this field, showing a positive trend of promising results, especially with the development of improved and environmentally friendly processes.
publishDate	2024
dc.date.accessioned.none.fl_str_mv	2024-10-24T12:17:32Z
dc.date.available.none.fl_str_mv	2024-10-24T12:17:32Z 2025-04-01
dc.date.issued.none.fl_str_mv	2024-04-01
dc.type.none.fl_str_mv	Artículo de revista
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.content.none.fl_str_mv	Text
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv	http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.coarversion.none.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
format	http://purl.org/coar/resource_type/c_2df8fbb1
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dc.identifier.citation.none.fl_str_mv	Viviane de Castro Bizerra, Rafael Leandro Fernandes Melo, Francisco Simão Neto, Erico Carlos de Castro, Misael Bessa Sales, Paulo Gonçalves de Sousa Junior, Dayana Nascimento Dari, Francisco Izaias da Silva Aires, Kaiany Moreira dos Santos, Juliana de França Serpa, Tak H. Kim, Jesús Fernández-Lucas, Maria Cristiane Martins de Souza, José C.S. dos Santos, Exploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering, Journal of Molecular Liquids, Volume 399, 2024, 124373, ISSN 0167-7322, https://doi.org/10.1016/j.molliq.2024.124373.
dc.identifier.issn.none.fl_str_mv	0167-7322
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/11323/13511
dc.identifier.doi.none.fl_str_mv	10.1016/j.molliq.2024.124373
dc.identifier.eissn.none.fl_str_mv	1873-3166
dc.identifier.instname.none.fl_str_mv	Corporación Universidad de la Costa
dc.identifier.reponame.none.fl_str_mv	REDICUC - Repositorio CUC
dc.identifier.repourl.none.fl_str_mv	https://repositorio.cuc.edu.co/
identifier_str_mv	Viviane de Castro Bizerra, Rafael Leandro Fernandes Melo, Francisco Simão Neto, Erico Carlos de Castro, Misael Bessa Sales, Paulo Gonçalves de Sousa Junior, Dayana Nascimento Dari, Francisco Izaias da Silva Aires, Kaiany Moreira dos Santos, Juliana de França Serpa, Tak H. Kim, Jesús Fernández-Lucas, Maria Cristiane Martins de Souza, José C.S. dos Santos, Exploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering, Journal of Molecular Liquids, Volume 399, 2024, 124373, ISSN 0167-7322, https://doi.org/10.1016/j.molliq.2024.124373. 0167-7322 10.1016/j.molliq.2024.124373 1873-3166 Corporación Universidad de la Costa REDICUC - Repositorio CUC
url	https://hdl.handle.net/11323/13511 https://repositorio.cuc.edu.co/
dc.language.iso.none.fl_str_mv	eng
language	eng
dc.relation.ispartofjournal.none.fl_str_mv	Journal of Molecular Liquids
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rights_invalid_str_mv	Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) © 2024 Elsevier B.V. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_f1cf
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publisher.none.fl_str_mv	Elsevier B.V.
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spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)© 2024 Elsevier B.V. All rights reserved.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/embargoedAccesshttp://purl.org/coar/access_right/c_f1cfCastro Bizerra, Viviane deFernandes Melo , Rafael LeandroSim˜ ao Neto, Franciscode Castro, Erico CarlosBessa Sales, MisaelPaulo Gonçalves de Sousa JuniorNascimento Dari, Dayanada Silva Aires, Francisco IzaiasMoreira dos Santos, KaianyFrança Serpa, Juliana deH. Kim, TakFernandez-Lucas, JesúsMartins de Souza, Maria Cristianedos Santos, Jose C.S.2024-10-24T12:17:32Z2025-04-012024-10-24T12:17:32Z2024-04-01Viviane de Castro Bizerra, Rafael Leandro Fernandes Melo, Francisco Simão Neto, Erico Carlos de Castro, Misael Bessa Sales, Paulo Gonçalves de Sousa Junior, Dayana Nascimento Dari, Francisco Izaias da Silva Aires, Kaiany Moreira dos Santos, Juliana de França Serpa, Tak H. Kim, Jesús Fernández-Lucas, Maria Cristiane Martins de Souza, José C.S. dos Santos, Exploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering, Journal of Molecular Liquids, Volume 399, 2024, 124373, ISSN 0167-7322, https://doi.org/10.1016/j.molliq.2024.124373.0167-7322https://hdl.handle.net/11323/1351110.1016/j.molliq.2024.1243731873-3166Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Ionic liquids (ILs) are widely used in many applications. Still, their use in enzyme engineering is particularly notable due to their environmentally friendly nature and efficient replacement of conventional organic solvents. Recently, lipase has emerged as an environmentally friendly catalyst. Nevertheless, using Lipases in the presence of ILs has led to a remarkable activity enhancement, making it a sustainable and non-harmful approach. This study conducted a bibliometric review of research articles published between 2010 and 2022 concerning the use of ILs in lipase-catalyzed reactions. The analysis was based on 206 publications retrieved from the Web of Science Core Collection (WoS) database., which were analyzed using different software tools, such as VOSviewer, CiteSpace, and ArcGIS. Key findings included that over half of the publications originated from other countries, notably China (around 36.4%), the United States, Spain, and France. As a result of this bibliometric analysis, four emerging trends were identified: namely: i) lipase-catalyzed synthesis, ii) the use of deep eutectic solvent, iii) the application of ILs in secondary alcohol reactions, iv) the use of ILs as green solvents, and iv) the enzymatic ring-opening polymerization. The study also evaluated the most prominent authors, articles, and institutions that provide comprehensive data on up-to-date research on ILs and lipases. It is noted that the studies identify significant advantages in this field, showing a positive trend of promising results, especially with the development of improved and environmentally friendly processes.19 páginasapplication/pdfengElsevier B.V.Netherlandshttps://www.sciencedirect.com/science/article/pii/S016773222400429X?via%3DihubExploring the synergy of ionic liquids and lipase in sustainable enzymatic engineeringArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Journal of Molecular Liquids[1] V. Sankar Sivasankarapillai, A. Sundararajan, E. Chonnur Easwaran, M. Pourmadadi, A. Aslani, R. Dhanusuraman, A. Rahdar, G.Z. Kyzas, Application of ionic liquids in rubber elastomers: perspectives and challenges, J. Mol. Liq. 382 (2023) 121846, https://doi.org/10.1016/J.MOLLIQ.2023.121846.[2] I. Ali, M. Hozaifa, S. 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Wang, Efficient synthesis of substituted pyrazoles via [3+2] cycloaddition catalyzed by lipase in ionic liquid, Process Biochem. 124 (2023) 253–258, https://doi.org/10.1016/j. procbio.2022.11.020191399Bibliometric analysisEnzyme engineeringIonic liquidsLipasePublicationORIGINALExploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering.pdfExploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering.pdfapplication/pdf10410641https://repositorio.cuc.edu.co/bitstreams/4277c9ad-0d87-45fc-9c91-e46381cbd907/download8a8f31ad532416ac2091d3906f89aff0MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-815543https://repositorio.cuc.edu.co/bitstreams/0660a0bb-6d5b-46f1-b46a-f8cf75ae46aa/download73a5432e0b76442b22b026844140d683MD52TEXTExploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering.pdf.txtExploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering.pdf.txtExtracted texttext/plain100415https://repositorio.cuc.edu.co/bitstreams/fc9b9c61-9bfb-4156-817f-376445f301b0/download7bc706988f7879751eac002bf6165980MD53THUMBNAILExploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering.pdf.jpgExploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering.pdf.jpgGenerated Thumbnailimage/jpeg14470https://repositorio.cuc.edu.co/bitstreams/f2f9f246-e4a5-424f-a66f-d72fe221c01d/download92524c6d90e359aab210ba22f1ea81a6MD5411323/13511oai:repositorio.cuc.edu.co:11323/135112024-10-25 03:01:31.536https://creativecommons.org/licenses/by-nc-nd/4.0/© 2024 Elsevier B.V. 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ara ejercer estos derechos sobre la Obra tal y como se indica a continuación:</p>
    <ol type="a">
      <li>Reproducir la Obra, incorporar la Obra en una o más Obras Colectivas, y reproducir la Obra incorporada en las Obras Colectivas.</li>
      <li>Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.</li>
      <li>Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.</li>
    </ol>
    <p>Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).</p>
  </li>
  <br/>
  <li>
    Restricciones.
    <p>La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:</p>
    <ol type="a">
      <li>Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).</li>
      <li>Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.</li>
      <li>Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.</li>
      <li>
        Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:
        <ol type="i">
          <li>Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.</li>
          <li>Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.</li>
        </ol>
      </li>
      <li>Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.</li>
    </ol>
  </li>
  <br/>
  <li>
    Representaciones, Garantías y Limitaciones de Responsabilidad.
    <p>A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.</p>
  </li>
  <br/>
  <li>
    Limitación de responsabilidad.
    <p>A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.</p>
  </li>
  <br/>
  <li>
    Término.
    <ol type="a">
      <li>Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.</li>
      <li>Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.</li>
    </ol>
  </li>
  <br/>
  <li>
    Varios.
    <ol type="a">
      <li>Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.</li>
      <li>Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.</li>
      <li>Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.</li>
      <li>Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.</li>
    </ol>
  </li>
  <br/>
</ol>


Exploring the synergy of ionic liquids and lipase in sustainable enzymatic engineering

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