COVID-19 mortality is attenuated at high tropical and subtropical altitude : an observational study of a database covering five Latin American countries
Pacientes con COVID-19
- Autores:
-
Zubieta-De Urioste, Natalia
Arias-Reyes, Christian
Sanchez, Lida
Armijo-Subieta, Nestor Freddy
Merino-Luna, Alfredo
Solarte, Ivan
Escalante-Kanashiro, Raffo
Carmona-Suazo, Jose Antonio
Maravi Poma, Enrique
Jimenez-Aguilar, Rosalinda
Calle-Aracena, Jose M.
Lopez-Bascope, Alberto
Vera, Roberto
Zubieta-DeUrioste, Rafaela
Rossel, Ninoska
Peña-Y-Lilio, Yeshua
Chambi-Quilla, Gary
Herrera-Leon, Luis
Garrido-Salazar, Santiago
Villacorta Cordova, Francisco Ney
Maldonado Coronel, Fausto Vinicio
Deindl, Elisabeth
Sheldon, Ricki
Accinelli, Roberto Alfonso
Schneider-Gasser, Edith M.
Soliz, Jorge
Zubieta-Calleja, Gustavo
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2023
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/65398
- Acceso en línea:
- https://esmed.org/MRA/mra/article/view/4299
http://hdl.handle.net/10554/65398
https://doi.org/10.18103/mra.v11i8.4299
- Palabra clave:
- SARS-CoV-2 first wave
ACE2
Chronic hypobaric hypoxia
Tolerance to hypoxia
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
COVID-19 mortality is attenuated at high tropical and subtropical altitude : an observational study of a database covering five Latin American countries |
| title |
COVID-19 mortality is attenuated at high tropical and subtropical altitude : an observational study of a database covering five Latin American countries |
| spellingShingle |
COVID-19 mortality is attenuated at high tropical and subtropical altitude : an observational study of a database covering five Latin American countries SARS-CoV-2 first wave ACE2 Chronic hypobaric hypoxia Tolerance to hypoxia |
| title_short |
COVID-19 mortality is attenuated at high tropical and subtropical altitude : an observational study of a database covering five Latin American countries |
| title_full |
COVID-19 mortality is attenuated at high tropical and subtropical altitude : an observational study of a database covering five Latin American countries |
| title_fullStr |
COVID-19 mortality is attenuated at high tropical and subtropical altitude : an observational study of a database covering five Latin American countries |
| title_full_unstemmed |
COVID-19 mortality is attenuated at high tropical and subtropical altitude : an observational study of a database covering five Latin American countries |
| title_sort |
COVID-19 mortality is attenuated at high tropical and subtropical altitude : an observational study of a database covering five Latin American countries |
| dc.creator.fl_str_mv |
Zubieta-De Urioste, Natalia Arias-Reyes, Christian Sanchez, Lida Armijo-Subieta, Nestor Freddy Merino-Luna, Alfredo Solarte, Ivan Escalante-Kanashiro, Raffo Carmona-Suazo, Jose Antonio Maravi Poma, Enrique Jimenez-Aguilar, Rosalinda Calle-Aracena, Jose M. Lopez-Bascope, Alberto Vera, Roberto Zubieta-DeUrioste, Rafaela Rossel, Ninoska Peña-Y-Lilio, Yeshua Chambi-Quilla, Gary Herrera-Leon, Luis Garrido-Salazar, Santiago Villacorta Cordova, Francisco Ney Maldonado Coronel, Fausto Vinicio Deindl, Elisabeth Sheldon, Ricki Accinelli, Roberto Alfonso Schneider-Gasser, Edith M. Soliz, Jorge Zubieta-Calleja, Gustavo |
| dc.contributor.author.none.fl_str_mv |
Zubieta-De Urioste, Natalia Arias-Reyes, Christian Sanchez, Lida Armijo-Subieta, Nestor Freddy Merino-Luna, Alfredo Solarte, Ivan Escalante-Kanashiro, Raffo Carmona-Suazo, Jose Antonio Maravi Poma, Enrique Jimenez-Aguilar, Rosalinda Calle-Aracena, Jose M. Lopez-Bascope, Alberto Vera, Roberto Zubieta-DeUrioste, Rafaela Rossel, Ninoska Peña-Y-Lilio, Yeshua Chambi-Quilla, Gary Herrera-Leon, Luis Garrido-Salazar, Santiago Villacorta Cordova, Francisco Ney Maldonado Coronel, Fausto Vinicio Deindl, Elisabeth Sheldon, Ricki Accinelli, Roberto Alfonso Schneider-Gasser, Edith M. Soliz, Jorge Zubieta-Calleja, Gustavo |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Neumología |
| dc.contributor.javerianateacher.none.fl_str_mv |
Solarte, Ivan |
| dc.subject.keyword.spa.fl_str_mv |
SARS-CoV-2 first wave ACE2 Chronic hypobaric hypoxia Tolerance to hypoxia |
| topic |
SARS-CoV-2 first wave ACE2 Chronic hypobaric hypoxia Tolerance to hypoxia |
| description |
Pacientes con COVID-19 |
| publishDate |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2023-09-07T15:06:35Z |
| dc.date.available.none.fl_str_mv |
2023-09-07T15:06:35Z |
| dc.date.created.none.fl_str_mv |
2023-08-31 |
| dc.type.local.spa.fl_str_mv |
Artículo de revista |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.identifier.spa.fl_str_mv |
https://esmed.org/MRA/mra/article/view/4299 |
| dc.identifier.issn.spa.fl_str_mv |
2375-1916 / 2375-1924 (Electrónico) |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/65398 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.18103/mra.v11i8.4299 |
| dc.identifier.instname.spa.fl_str_mv |
instname:Pontificia Universidad Javeriana |
| dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
| dc.identifier.repourl.spa.fl_str_mv |
repourl:https://repository.javeriana.edu.co |
| url |
https://esmed.org/MRA/mra/article/view/4299 http://hdl.handle.net/10554/65398 https://doi.org/10.18103/mra.v11i8.4299 |
| identifier_str_mv |
2375-1916 / 2375-1924 (Electrónico) instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
1 |
| dc.relation.citationendpage.spa.fl_str_mv |
19 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Medical Research Archives |
| dc.relation.citationvolume.spa.fl_str_mv |
11 |
| dc.relation.citationissue.spa.fl_str_mv |
8 |
| dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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PDF |
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application/pdf |
| dc.coverage.spatial.spa.fl_str_mv |
América Latina Bolivia Colombia Ecuador México Perú |
| dc.coverage.temporal.spa.fl_str_mv |
2020-2021 |
| institution |
Pontificia Universidad Javeriana |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Zubieta-De Urioste, NataliaArias-Reyes, ChristianSanchez, LidaArmijo-Subieta, Nestor FreddyMerino-Luna, AlfredoSolarte, IvanEscalante-Kanashiro, RaffoCarmona-Suazo, Jose AntonioMaravi Poma, EnriqueJimenez-Aguilar, RosalindaCalle-Aracena, Jose M.Lopez-Bascope, AlbertoVera, RobertoZubieta-DeUrioste, RafaelaRossel, NinoskaPeña-Y-Lilio, YeshuaChambi-Quilla, GaryHerrera-Leon, LuisGarrido-Salazar, SantiagoVillacorta Cordova, Francisco NeyMaldonado Coronel, Fausto VinicioDeindl, ElisabethSheldon, RickiAccinelli, Roberto AlfonsoSchneider-Gasser, Edith M.Soliz, JorgeZubieta-Calleja, GustavoPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. NeumologíaSolarte, IvanAmérica LatinaBoliviaColombiaEcuadorMéxicoPerú2020-20212023-09-07T15:06:35Z2023-09-07T15:06:35Z2023-08-31https://esmed.org/MRA/mra/article/view/42992375-1916 / 2375-1924 (Electrónico)http://hdl.handle.net/10554/65398https://doi.org/10.18103/mra.v11i8.4299instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengCOVID-19 mortality is attenuated at high tropical and subtropical altitude : an observational study of a database covering five Latin American countriesArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Pacientes con COVID-19The COVID-19 pandemic, caused by the SARS-COV-2 virus, has had devastating consequences worldwide. Remarkably, the incidence, virus transmission capacity, and severity of COVID-19 have been reported to be significantly decreased in high-altitude human populations. The clinical significance of these findings is enormous, as they suggest that permanent inhabitants of high altitudes have developed adaptive protective changes against certain pathologies. However, these observations have been overshadowed by contradictory reports on the COVID-19 mortality rate at high altitude, ascribed to low population densities. These interpretations, however, fail to consider that the environmental conditions of high-altitude regions of the temperate and tropical geographical zones are radically different from each other. Contrary to common thought, the conditions of high-altitude areas of countries within the tropical zone are so benign that they have favored the growth and development of densely populated cities. In this work, we use data from a COVID-19 database covering five Latin American countries in the tropical and subtropical geographic zone that corresponded to the period between the start of the pandemic and the end of 2020, when no vaccine was yet available. Our results reveal that residing above 1,000 m in tropical countries was a protective factor against COVID-19 mortality. Interestingly, this protective effect was independent of population size. The findings presented here, and those from other similar studies, substantiate the need for more research to reveal the secrets of the physiology of permanent high-altitude residents. In conclusion, our findings clearly demonstrate that the high-altitude environment in tropical and subtropical geographic zones significantly contributes to the decreased mortality impact of the SARS-COV-2 virus in high-altitude-exposed populations.https://orcid.org/0000-0002-0100-1940Revista Internacional - No indexadaNoSARS-CoV-2 first waveACE2Chronic hypobaric hypoxiaTolerance to hypoxia119Medical Research Archives118ORIGINALCOVID-19 Mortality Is Attenuated at High Tropical and Subtropical Altitude An Observational Study of a Database Covering Five Latin American Countri.pdfCOVID-19 Mortality Is Attenuated at High Tropical and Subtropical Altitude An Observational Study of a Database Covering Five Latin American Countri.pdfArtículoapplication/pdf1068149http://repository.javeriana.edu.co/bitstream/10554/65398/1/COVID-19%20Mortality%20Is%20Attenuated%20at%20High%20Tropical%20and%20Subtropical%20Altitude%20An%20Observational%20Study%20of%20a%20Database%20Covering%20Five%20Latin%20American%20Countri.pdf0c5040c8aaba96250ab9209e482f43e4MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/65398/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILCOVID-19 Mortality Is Attenuated at High Tropical and Subtropical Altitude An Observational Study of a Database Covering Five Latin American Countri.pdf.jpgCOVID-19 Mortality Is Attenuated at High Tropical and Subtropical Altitude An Observational Study of a Database Covering Five Latin American Countri.pdf.jpgIM Thumbnailimage/jpeg11504http://repository.javeriana.edu.co/bitstream/10554/65398/3/COVID-19%20Mortality%20Is%20Attenuated%20at%20High%20Tropical%20and%20Subtropical%20Altitude%20An%20Observational%20Study%20of%20a%20Database%20Covering%20Five%20Latin%20American%20Countri.pdf.jpg6c68b198fd8b954461d82b965ad701ceMD53open access10554/65398oai:repository.javeriana.edu.co:10554/653982024-01-11 18:13:03.204Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |