Type 2 inflammation in asthma and other airway diseases
Q2
- Autores:
-
Maspero, Jorge
Adir, Yochai
Ahmad, Mona Al
Celis-Preciado, Carlos Andrés
Colodenco, Federico D.
Bianchi, Pedro Giavina
Lababidi, Hani
Ledanois, Olivier
Mahoub, Bassam
Warng Perng, Diahn
Vazquez, Juan C.
Yorgancioglu, Arzu
- Tipo de recurso:
- Article of data
- Fecha de publicación:
- 2022
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/61599
- Acceso en línea:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339769/
http://hdl.handle.net/10554/61599
https://doi.org/10.1183/23120541.00576-2021
- Palabra clave:
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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Type 2 inflammation in asthma and other airway diseases |
| title |
Type 2 inflammation in asthma and other airway diseases |
| spellingShingle |
Type 2 inflammation in asthma and other airway diseases |
| title_short |
Type 2 inflammation in asthma and other airway diseases |
| title_full |
Type 2 inflammation in asthma and other airway diseases |
| title_fullStr |
Type 2 inflammation in asthma and other airway diseases |
| title_full_unstemmed |
Type 2 inflammation in asthma and other airway diseases |
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Type 2 inflammation in asthma and other airway diseases |
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Maspero, Jorge Adir, Yochai Ahmad, Mona Al Celis-Preciado, Carlos Andrés Colodenco, Federico D. Bianchi, Pedro Giavina Lababidi, Hani Ledanois, Olivier Mahoub, Bassam Warng Perng, Diahn Vazquez, Juan C. Yorgancioglu, Arzu |
| dc.contributor.author.none.fl_str_mv |
Maspero, Jorge Adir, Yochai Ahmad, Mona Al Celis-Preciado, Carlos Andrés Colodenco, Federico D. Bianchi, Pedro Giavina Lababidi, Hani Ledanois, Olivier Mahoub, Bassam Warng Perng, Diahn Vazquez, Juan C. Yorgancioglu, Arzu |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Neumología |
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Celis-Preciado, Carlos Andrés |
| description |
Q2 |
| publishDate |
2022 |
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2022-09-02T16:30:24Z |
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2022-09-02T16:30:24Z |
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2022-08-01 |
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Artículo de revisión |
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339769/ |
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2312-0541 |
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http://hdl.handle.net/10554/61599 |
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https://doi.org/10.1183/23120541.00576-2021 |
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339769/ http://hdl.handle.net/10554/61599 https://doi.org/10.1183/23120541.00576-2021 |
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eng |
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eng |
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1 |
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ERJ Open Research |
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8 |
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Atribución-NoComercial 4.0 Internacional |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Maspero, JorgeAdir, YochaiAhmad, Mona AlCelis-Preciado, Carlos AndrésColodenco, Federico D.Bianchi, Pedro GiavinaLababidi, HaniLedanois, OlivierMahoub, BassamWarng Perng, DiahnVazquez, Juan C.Yorgancioglu, ArzuPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. NeumologíaCelis-Preciado, Carlos Andrés2022-09-02T16:30:24Z2022-09-02T16:30:24Z2022-08-01https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339769/2312-0541http://hdl.handle.net/10554/61599https://doi.org/10.1183/23120541.00576-2021instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengType 2 inflammation in asthma and other airway diseasesArtículo de revisiónhttp://purl.org/coar/resource_type/c_beb9Q2Q1Pacientes con AsmaChronic inflammatory airway diseases, including asthma, chronic rhinosinusitis, eosinophilic COPD and allergic rhinitis are a global health concern. Despite the coexistence of these diseases and their common pathophysiology, they are often managed independently, resulting in poor asthma control, continued symptoms and poor quality of life. Understanding disease pathophysiology is important for best treatment practice, reduced disease burden and improved patient outcomes. The pathophysiology of type 2 inflammation is driven by both the innate immune system triggered by pollutants, viral or fungal infections involving type 2 innate lymphoid cells (ILC2) and the adaptive immune system, triggered by contact with an allergen involving type 2 T-helper (Th2) cells. Both ILC2 and Th2 cells produce the type-2 cytokines (interleukin (IL)-4, IL-5 and IL-13), each with several roles in the inflammation cascade. IL-4 and IL-13 cause B-cell class switching and IgE production, release of proinflammatory mediators, barrier disruption and tissue remodelling. In addition, IL-13 causes goblet-cell hyperplasia and mucus production. All three interleukins are involved in trafficking eosinophils to tissues, producing clinical symptoms characteristic of chronic inflammatory airway diseases. Asthma is a heterogenous disease; therefore, identification of biomarkers and early targeted treatment is critical for patients inadequately managed by inhaled corticosteroids and long-acting β-agonists alone. The Global Initiative for Asthma guidelines recommend add-on biological (anti IgE, IL-5/5R, IL-4R) treatments for those not responding to standard of care. Targeted therapies, including omalizumab, mepolizumab, reslizumab, benralizumab, dupilumab and tezepelumab, were developed on current understanding of the pathophysiology of type 2 inflammation. These therapies offer hope for improved management of type 2 inflammatory airway diseases.https://orcid.org/0000-0001-8405-4513https://scholar.google.es/citations?user=1UDmoyQAAAAJ&hl=esRevista Internacional - IndexadaBNo119ERJ Open Research83ORIGINALmaspero-2022-Type 2 inflammation in asthma and other airway diseases.pdfmaspero-2022-Type 2 inflammation in asthma and other airway diseases.pdfArtículoapplication/pdf737905http://repository.javeriana.edu.co/bitstream/10554/61599/1/maspero-2022-Type%202%20inflammation%20in%20asthma%20and%20other%20airway%20diseases.pdf288b07263dcaa66e60035e7592605522MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/61599/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILmaspero-2022-Type 2 inflammation in asthma and other airway diseases.pdf.jpgmaspero-2022-Type 2 inflammation in asthma and other airway diseases.pdf.jpgIM Thumbnailimage/jpeg10550http://repository.javeriana.edu.co/bitstream/10554/61599/3/maspero-2022-Type%202%20inflammation%20in%20asthma%20and%20other%20airway%20diseases.pdf.jpg2f8dcb008a3ecc49872f60f52dacf044MD53open access10554/61599oai:repository.javeriana.edu.co:10554/615992023-05-18 12:56:10.817Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |