Nanotecnología aplicada al diagnóstico y tratamiento del cáncer tipo carcinoma

El cáncer es la segunda enfermedad con mayor índice de mortalidad a nivel mundial. Según las estimaciones mundiales proporcionadas por GLOBOCAN, se prevé que la incidencia del cáncer aumente significativamente para el año 2040, con una estimación de 30,2 millones de nuevos casos y 16,3 millones de m...

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Autores:
Hernandez Benitez, Natalia Andrea
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2024
Institución:
Universidad ICESI
Repositorio:
Repositorio ICESI
Idioma:
spa
OAI Identifier:
oai:repository.icesi.edu.co:10906/130184
Acceso en línea:
https://hdl.handle.net/10906/130184
https://biblioteca2.icesi.edu.co/cgi-olib/?oid=363915
Palabra clave:
Nanotecnología
Cáncer tipo carcinoma
Diagnóstico del cáncer
Tratamiento del cáncer
Marcadores moleculares
Trabajos de grado de Biología
Nanotechnology
Carcinoma Cancer
Cancer Diagnosis
Cancer Treatment
Molecular Markers
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/4.0/
id ICESI2_bb74a98203d1a01e9b5872a367ec8977
oai_identifier_str oai:repository.icesi.edu.co:10906/130184
network_acronym_str ICESI2
network_name_str Repositorio ICESI
repository_id_str
dc.title.spa.fl_str_mv Nanotecnología aplicada al diagnóstico y tratamiento del cáncer tipo carcinoma
title Nanotecnología aplicada al diagnóstico y tratamiento del cáncer tipo carcinoma
spellingShingle Nanotecnología aplicada al diagnóstico y tratamiento del cáncer tipo carcinoma
Nanotecnología
Cáncer tipo carcinoma
Diagnóstico del cáncer
Tratamiento del cáncer
Marcadores moleculares
Trabajos de grado de Biología
Nanotechnology
Carcinoma Cancer
Cancer Diagnosis
Cancer Treatment
Molecular Markers
title_short Nanotecnología aplicada al diagnóstico y tratamiento del cáncer tipo carcinoma
title_full Nanotecnología aplicada al diagnóstico y tratamiento del cáncer tipo carcinoma
title_fullStr Nanotecnología aplicada al diagnóstico y tratamiento del cáncer tipo carcinoma
title_full_unstemmed Nanotecnología aplicada al diagnóstico y tratamiento del cáncer tipo carcinoma
title_sort Nanotecnología aplicada al diagnóstico y tratamiento del cáncer tipo carcinoma
dc.creator.fl_str_mv Hernandez Benitez, Natalia Andrea
dc.contributor.advisor.none.fl_str_mv Pinillos Madrid, Juan Fernando
dc.contributor.author.none.fl_str_mv Hernandez Benitez, Natalia Andrea
dc.subject.proposal.spa.fl_str_mv Nanotecnología
Cáncer tipo carcinoma
Diagnóstico del cáncer
Tratamiento del cáncer
Marcadores moleculares
Trabajos de grado de Biología
topic Nanotecnología
Cáncer tipo carcinoma
Diagnóstico del cáncer
Tratamiento del cáncer
Marcadores moleculares
Trabajos de grado de Biología
Nanotechnology
Carcinoma Cancer
Cancer Diagnosis
Cancer Treatment
Molecular Markers
dc.subject.proposal.eng.fl_str_mv Nanotechnology
Carcinoma Cancer
Cancer Diagnosis
Cancer Treatment
Molecular Markers
description El cáncer es la segunda enfermedad con mayor índice de mortalidad a nivel mundial. Según las estimaciones mundiales proporcionadas por GLOBOCAN, se prevé que la incidencia del cáncer aumente significativamente para el año 2040, con una estimación de 30,2 millones de nuevos casos y 16,3 millones de muertes causadas por la enfermedad. Entre las medidas esenciales para garantizar un tratamiento más eficaz contra el cáncer se encuentran la identificación temprana de las células malignas, así como la administración de fármacos que posean una especificidad alta para minimizar las reacciones adversas. No obstante, todavía existen muchas limitaciones en la vigilancia, el diagnóstico y el tratamiento del cáncer como las altas toxicidades sistémicas, la aparición de mecanismos de resistencia, la farmacocinética deficiente, la baja eficiencia de administración de los medicamentos y la falta de métodos de diagnóstico temprano. Por lo tanto, puesto que el cáncer no es una única enfermedad, sino que cada tipo de cáncer se manifiesta de manera distinta, el campo de la medicina ha tenido que desarrollar urgentemente estrategias mejoradas e innovadoras para el diagnóstico temprano y tratamiento eficaz del cáncer, y la nanomedicina, se perfila como un enfoque terapéutico prometedor al poseer un inmenso potencial para revolucionar el campo del diagnóstico y la terapia del cáncer mediante la incorporación de materiales o dispositivos nanoestructurados como portadores de nanofármacos, sondas de diagnóstico, biosensores, plataformas de microfluidos y agentes de contraste para imágenes médicas. Palabras clave: Nanotecnología, cáncer tipo carcinoma, diagnóstico del cáncer, tratamiento del cáncer, marcadores moleculares.
publishDate 2024
dc.date.issued.none.fl_str_mv 2024-06-11
dc.date.accessioned.none.fl_str_mv 2025-03-12T16:49:58Z
dc.date.available.none.fl_str_mv 2025-03-12T16:49:58Z
dc.type.none.fl_str_mv bachelor thesis
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dc.type.local.none.fl_str_mv Trabajo de grado
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url https://hdl.handle.net/10906/130184
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dc.language.iso.none.fl_str_mv spa
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spelling Pinillos Madrid, Juan FernandoHernandez Benitez, Natalia AndreaCali de Lat: 03 24 00 N degrees minutes Lat: 3.4000 decimal degrees Long: 076 30 00 W degrees minutes Long: -76.5000 decimal degrees.2025-03-12T16:49:58Z2025-03-12T16:49:58Z2024-06-11https://hdl.handle.net/10906/130184https://biblioteca2.icesi.edu.co/cgi-olib/?oid=363915El cáncer es la segunda enfermedad con mayor índice de mortalidad a nivel mundial. Según las estimaciones mundiales proporcionadas por GLOBOCAN, se prevé que la incidencia del cáncer aumente significativamente para el año 2040, con una estimación de 30,2 millones de nuevos casos y 16,3 millones de muertes causadas por la enfermedad. Entre las medidas esenciales para garantizar un tratamiento más eficaz contra el cáncer se encuentran la identificación temprana de las células malignas, así como la administración de fármacos que posean una especificidad alta para minimizar las reacciones adversas. No obstante, todavía existen muchas limitaciones en la vigilancia, el diagnóstico y el tratamiento del cáncer como las altas toxicidades sistémicas, la aparición de mecanismos de resistencia, la farmacocinética deficiente, la baja eficiencia de administración de los medicamentos y la falta de métodos de diagnóstico temprano. Por lo tanto, puesto que el cáncer no es una única enfermedad, sino que cada tipo de cáncer se manifiesta de manera distinta, el campo de la medicina ha tenido que desarrollar urgentemente estrategias mejoradas e innovadoras para el diagnóstico temprano y tratamiento eficaz del cáncer, y la nanomedicina, se perfila como un enfoque terapéutico prometedor al poseer un inmenso potencial para revolucionar el campo del diagnóstico y la terapia del cáncer mediante la incorporación de materiales o dispositivos nanoestructurados como portadores de nanofármacos, sondas de diagnóstico, biosensores, plataformas de microfluidos y agentes de contraste para imágenes médicas. Palabras clave: Nanotecnología, cáncer tipo carcinoma, diagnóstico del cáncer, tratamiento del cáncer, marcadores moleculares.Resumen ejecutivo -- Introducción -- Nanotecnología -- Aplicaciones de la nanotecnología en el diagnóstico y tratamiento del cáncer -- Conclusiones -- Agradecimientos -- Referencias bibliográficas87 páginasapplication/pdfspaUniversidad IcesiBarberi de Ingeniería, Diseño y Ciencias AplicadasBiologíaSantiago de CaliEL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://purl.org/coar/access_right/c_abf2Nanotecnología aplicada al diagnóstico y tratamiento del cáncer tipo carcinomabachelor thesishttp://purl.org/coar/resource_type/c_7a1fTrabajo de gradoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/bachelorThesisTodo PúblicoNanotecnologíaCáncer tipo carcinomaDiagnóstico del cáncerTratamiento del cáncerMarcadores molecularesTrabajos de grado de BiologíaNanotechnologyCarcinoma CancerCancer DiagnosisCancer TreatmentMolecular MarkersSakore, P., Bhattacharya, S., Belemkar, S., Prajapati, B. 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ACS Appl Mater Interfaces 9 , 3985–3994 (2017).ORIGINALTG03967.pdfTG03967.pdfapplication/pdf1229875https://repository.icesi.edu.co/bitstreams/f9894ceb-009f-4fc7-b3a3-36476cf2c557/download39870d2416425045f85522ff1902f3d5MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8899https://repository.icesi.edu.co/bitstreams/f266d497-1c14-47d7-af79-00d9afa7882c/download3b6ce8e9e36c89875e8cf39962fe8920MD52LICENSElicense.txtlicense.txttext/plain1748https://repository.icesi.edu.co/bitstreams/91580910-3140-425f-bf45-e5d112585137/downloadbb9bdc0b3349e4284e09149f943790b4MD5310906/130184oai:repository.icesi.edu.co:10906/1301842025-03-12 11:49:58.946http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalopen.accesshttps://repository.icesi.edu.coBiblioteca Digital - Universidad Icesiadquisicion-bib@listas.icesi.edu.coTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0IG93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLCB0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZyB0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sIGluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlIHN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yIHB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZSB0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQgdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uIGFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LCB5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZSBjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdCBzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkIHdpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRCBCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUgRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSCBDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZSBzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMgbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=