Aplicaciones cosméticas y estéticas del ácido hialurónico

This project aimed at the exhaustive compilation and consolidation of information on the cosmetic and aesthetic applications of hyaluronic acid in America and Europe during the last two decades. Its versatility, ability to provide volume, and maintain skin hydration have boosted its use as the most...

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Autores:
Castillo Bravo, Gabriela
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2024
Institución:
Universidad ICESI
Repositorio:
Repositorio ICESI
Idioma:
spa
OAI Identifier:
oai:repository.icesi.edu.co:10906/130349
Acceso en línea:
https://hdl.handle.net/10906/130349
https://biblioteca2.icesi.edu.co/cgi-olib/?oid=365030
Palabra clave:
Ácido hialurónico
Cosmética
Estética
Relleno de tejidos blandos
Relleno dérmico
Trabajo de grado de Química Farmacéutica
Hyaluronic acid
Cosmetics
Aesthetics
Soft tissue filler
Dermal filler
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/4.0/
id ICESI2_122138349dcb4f758eb5af7534ba3a57
oai_identifier_str oai:repository.icesi.edu.co:10906/130349
network_acronym_str ICESI2
network_name_str Repositorio ICESI
repository_id_str
dc.title.spa.fl_str_mv Aplicaciones cosméticas y estéticas del ácido hialurónico
title Aplicaciones cosméticas y estéticas del ácido hialurónico
spellingShingle Aplicaciones cosméticas y estéticas del ácido hialurónico
Ácido hialurónico
Cosmética
Estética
Relleno de tejidos blandos
Relleno dérmico
Trabajo de grado de Química Farmacéutica
Hyaluronic acid
Cosmetics
Aesthetics
Soft tissue filler
Dermal filler
title_short Aplicaciones cosméticas y estéticas del ácido hialurónico
title_full Aplicaciones cosméticas y estéticas del ácido hialurónico
title_fullStr Aplicaciones cosméticas y estéticas del ácido hialurónico
title_full_unstemmed Aplicaciones cosméticas y estéticas del ácido hialurónico
title_sort Aplicaciones cosméticas y estéticas del ácido hialurónico
dc.creator.fl_str_mv Castillo Bravo, Gabriela
dc.contributor.advisor.none.fl_str_mv Velásquez García, Natalia
dc.contributor.author.none.fl_str_mv Castillo Bravo, Gabriela
dc.subject.proposal.spa.fl_str_mv Ácido hialurónico
Cosmética
Estética
Relleno de tejidos blandos
Relleno dérmico
Trabajo de grado de Química Farmacéutica
topic Ácido hialurónico
Cosmética
Estética
Relleno de tejidos blandos
Relleno dérmico
Trabajo de grado de Química Farmacéutica
Hyaluronic acid
Cosmetics
Aesthetics
Soft tissue filler
Dermal filler
dc.subject.proposal.eng.fl_str_mv Hyaluronic acid
Cosmetics
Aesthetics
Soft tissue filler
Dermal filler
description This project aimed at the exhaustive compilation and consolidation of information on the cosmetic and aesthetic applications of hyaluronic acid in America and Europe during the last two decades. Its versatility, ability to provide volume, and maintain skin hydration have boosted its use as the most popular injectable filler in aesthetic medicine, covering a wide range of applications as topical products and facial and body dermal fillers. Through the review of databases such as Nature, Science Direct, Latindex, Oxford Academic, and Sage Journals, 7863 articles were collected, from which 60 were selected, meeting the required selection criteria. The information obtained was classified into general categories covering the lower third, middle third, upper third, body, comprehensive facial treatment, topical application, and complementary articles. This allowed addressing the generalities, applications, safety profiles, benefits, and potential complications of hyaluronic acid use. The reviewed studies confirm that hyaluronic acid offers a non-invasive alternative to traditional surgical methods, with reduced recovery times and adaptability to the anatomical characteristics of each patient. Regarding complications, it was found that, despite its high safety profile, mild complications such as swelling, bruising, and redness have been reported, as well as some more serious ones like vascular occlusions, granulomas, and infections which, although rare, require attention to prevent or treat them promptly.
publishDate 2024
dc.date.issued.none.fl_str_mv 2024-12-12
dc.date.accessioned.none.fl_str_mv 2025-06-13T16:49:59Z
dc.date.available.none.fl_str_mv 2025-06-13T16:49:59Z
dc.type.none.fl_str_mv bachelor thesis
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.local.none.fl_str_mv Trabajo de grado
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
format http://purl.org/coar/resource_type/c_7a1f
status_str publishedVersion
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10906/130349
dc.identifier.OLIB.none.fl_str_mv https://biblioteca2.icesi.edu.co/cgi-olib/?oid=365030
dc.identifier.instname.none.fl_str_mv instname:Universidad Icesi
dc.identifier.reponame.none.fl_str_mv reponame:Biblioteca Digital
dc.identifier.repourl.none.fl_str_mv repourl:https://repository.icesi.edu.co/
url https://hdl.handle.net/10906/130349
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identifier_str_mv instname:Universidad Icesi
reponame:Biblioteca Digital
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dc.language.iso.none.fl_str_mv spa
language spa
dc.relation.references.spa.fl_str_mv 1. Krutyansky, A., Halepas, S. & Ferneini, E. M. Cosmetic surgery. Oral Maxillofac Surg Cases 9 , (2023).
2. Shikina, E. V., Kovalevsky, R. A., Shirkovskaya, A. I. & Toukach, P. V. Prospective bacterial and fungal sources of hyaluronic acid: A review. Computational and Structural Biotechnology Journal vol. 20 6214 – 6236 Preprint at https://doi.org/10.1016/j.csbj.2022.11.013 (2022).
3. Micromedex. HYALURONIC ACID . https://nebulosa.icesi.edu.co:2344/micromedex2/librarian/CS/04DE74/ND_PR/evidencexpert/ND _P/evidencexpert/DUPLICATIONSHIELDSYNC/1D1FF9/ND_P (2024).
4. Fink, J. K. The Chemistry of Bio - Based Polymers: Medical Applications. (2020).
5. Ozturk, S., Ayanoğlu, F. B., Parmaksiz, M., Elçin, A. E. & Elçin, Y. M. Clinical and surgical aspects of medical materials’ biocompatibility. in Handbook of Biomaterials Biocompatibility 219 – 250 (Elsevier, 2020). doi:10.1016/B978 - 0 - 08 - 102967 - 1.00012 - 8.
6. Meyer, H. - P. Biotechnology for the Production of Chemicals, Intermediates, and Pharmaceutical Ingredients . (2016).
7. Hyaluronic Acid. Thieme Medical Publishers 665 – 666 (2009).
8. Pires Viana, G. André. H. O. Midori. C. A. Júlio. W. D. Renato. H. O. T. Treatment With Hyaluronic Acid Fillers . vol. 23 www.cosderm.com (2010).
9. Crowley, E., Dalton, M. & Burke, G. Cytotoxicity and biocompatibility of bioresorbable polymers. in Bioresorbable Polymers: Biomedical Applications 101 – 120 (De Gruyter, 2019). doi:10.1515/9783110640571 - 006.
10. Antonio, C. R. & Trídico, L. A. The importance of interaction between hyaluronic acid and CD44 receptor. Surgical and Cosmetic Dermatology 13 , (2021).
11. Scardovi, S., Goglian, A., Gendra, P. & Gendra, C. Estudio clínico de eficacia, duración y efectos adversos del implante de Ácido Hialurónico en el área Buco - Maxilo - Facial Clinical study of the efficacy, duration and adverse effects of Hyaluronic Acid implants in the Oral - Maxillofacial area. 30 (2017) doi:10.22592/o2017n30a9.
12. Hermans, A. M. Lifting, sculpting, and contouring: Implications of the blurred boundary between cosmetic procedures and ‘other’ beauty products/services. Poetics 90 , (2022).
13. Sánchez - Carpintero, I., Candelas, D. & Ruiz - Rodríguez, R. Dermal Fillers: Types, Indications, and Complications. Actas Dermo - Sifiliográficas (English Edition) 101 , 381 – 393 (2010).
14. Zhao, F., Chen, Y., He, D., You, X. & Xu, Y. Disastrous cerebral and ocular vascular complications after cosmetic facial filler injections: a retrospective case series study. Sci Rep 14 , (2024).
15. FDA. FDA Dermal Fillers. (2024).
16. FDA. FDA Approved Dermal Fillers. (2024).
17. Frisina, A. C., Barbosa, B. de O., Teixeira, G. H. D. C. & Fernandes, R. L. Nasal reshaping with hyaluronic acid: Technique, risks, and benefits. Revista Brasileira de Cirurgia Plastica 36 , 108 – 114 (2021).
18. Lipko - Godlewska, S. et al. Whole - face approach with hyaluronic acid fillers. Clinical, Cosmetic and Investigational Dermatology vol. 14 169 – 178 Preprint at https://doi.org/10.2147/CCID.S292501 (2021).
19. Wypych, G. Functional Fillers: Applications: Soft Tissue - fillers. ChemTec Publishing 249 – 251 (2023).
20. Bertossi, D. et al. Nonsurgical Redefinition of the Chin and Jawline of Younger Adults with a Hyaluronic Acid Filler: Results Evaluated with a Grid System Approach. Aesthet Surg J 41 , 1068 – 1076 (2021).
21. Mahmood Faris, B. J. The Use of Facial Fillers in Clinical Practice: The Level of Patient Satisfaction and an Overview of Common Clinical Complications. Actas Dermosifiliogr 115 , 458 – 465 (2024).
22. Cavallini, M., Gazzola, R., Metalla, M. & Vaienti, L. The role of hyaluronidase in the treatment of complications from hyaluronic acid dermal fillers. Aesthetic Surgery Journal vol. 33 1167 – 1174 Preprint at https://doi.org/10.1177/1090820X13511970 (2013).
23. Sue, G. R., Seither, J. G. & Nguyen, D. H. Use of hyaluronic acid filler for enhancement of nipple projection following breast reconstruction: An easy and effective technique. JPRAS Open 23 , 19 – 25 (2020).
24. Ordynowski, L. Cross - Linked Hyaluronic Acid for Cleft Lip and Palate Aesthetic Correction: A Preliminary Report. Aesthet Surg J Open Forum 4 , (2022).
25. Biesman, B. S. et al. A Multicenter, Randomized, Evaluator - Blinded Study to Examine the Safety and Effectiveness of Hyaluronic Acid Filler in the Correction of Infraorbital Hollows. Aesthet Surg J (2024) doi:10.1093/asj/sjae073.
26. Lambros, V. Volumizing the brow with hyaluronic acid fillers. Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery 29 , 174 – 179 (2009).
27. Hedén, P. & Sinna, R. An open, prospective study to evaluate the effectiveness and safety of hyaluronic acid for pectus excavatum treatment. Aesthet Surg J 39 , NP189 – NP201 (2018).
28. Colbert, S. D., Southorn, B. J., Brennan, P. A. & Ilankovan, V. Perils of dermal fillers. Br Dent J 214 , 339 – 340 (2013).
29. Germani, M., Alegria, P., Giro, G. & Munoz - Lora, V. R. M. High - dose pulsed hyaluronidase for managing nasal skin necrosis following hyaluronic acid treatment in nasolabial folds: A case report. J Oral Biol Craniofac Res 14 , 339 – 341 (2024).
30. Soares, D. J. & Zuliani, G. F. Orbital post - septal hyaluronic acid: An iatrogenic etiology compounding lower eyelid steatoblepharon. JPRAS Open 34 , 173 – 177 (2022).
31. Szwed, M., Szwed, W., Szwed, J. & Miga, N. HA (hyaluronic acid) fillers in aesthetic medicine - the most common complications. Journal of Education, Health and Sport 12 , 722 – 729 (2022).
32. Di Santis, É. P., Yarak, S., Martins, M. R. & Hirata, S. H. Compulsory notification of injuries in aesthetic procedures. Impact on patient safety. An Bras Dermatol 97 , 491 – 497 (2022).
33. de Queiroz Hernandez, P. M. et al. Evaluation of the attractiveness of lips with different volumes after filling with hyaluronic acid. Sci Rep 13 , (2023).
34. Rivkin, A. et al. Safe and Effective Restoration of Jawline Definition With Hyaluronic Acid Injectable Gel 4 VYC - 25L: Results From a Randomized Controlled Study. COSMETIC MEDICINE (2024) doi:10.1093/asj/sjae147/7710605.
35. Alhallak, K., Omran, D. & Tomi, S. Achieving Bratz Doll Look with Lip Fillers: A Prospective Observational Study on Blunt Cannula Techniques. Plast Reconstr Surg Glob Open 12 , E5731 (2024).
36. Swallow, M., Elgash, M., Kim, S. R., Hinchcliff, M. & Suozzi, K. Hyaluronic acid filler for lip augmentation in patients with systemic sclerosis: A prospective cohort study. JAAD Case Rep 49 , 79 – 81 (2024).
37. Serge A. Steenen, C. G. B. B. van der L. N. S. M. van E. R. A. - S. W. K. T. J. Y. H. J. de L. Head - to - head comparison of 4 hyaluronic acid dermal fillers for lip augmentation: A multicenter randomized, quadruple - blind, controlled clinical trial. Dermatologic Surgery 39 , 932 – 935 (2023).
38. Bertossi, D., Malchiodi, L., Albanese, M., Nocini, R. & Nocini, P. Nonsurgical Rhinoplasty with the Novel Hyaluronic Acid Filler VYC - 25L: Results Using a Nasal Grid Approach. Aesthet Surg J 41 , NP512 – NP520 (2020).
39. De Boulle, K. et al. Considerations for the use of minimally invasive aesthetic procedures for facial remodeling in transgender individuals. Clin Cosmet Investig Dermatol 14 , 513 – 525 (2021).
40. Dall’Magro, A. K. et al. Choosing Juvéderm Volux TM to chin augmentation: Case report and flowchart for clinical evaluation. Int J Surg Case Rep 114 , (2024).
41. Taylor, S. et al. Effectiveness and Safety of Resilient Hyaluronic Acid (RHA) Dermal Fillers for the Correction of Moderate - to - Severe Nasolabial Folds in People of Color: Post Hoc Subgroup Analyses of US Pivotal Clinical Data. Aesthet Surg J 44 , 412 – 420 (2024).
42. Zatta da Silva, T. et al. Hyaluronic acid for repairing interdental papilla in esthetic area: case report. Revista clínica de periodoncia, implantología y rehabilitación oral 12 , 157 – 158 (2019).
43. Iribarra - Leigh, J. et al. Remodelación de papila gingival interdental con ácido hialurónico. Una solución estética. Revista clínica de periodoncia, implantología y rehabilitación oral 12 , 151 – 153 (2019).
44. Celória, A., Alberto Sigua - Rodriguez, E. & Olate, S. Aumento Gingival En Base a Ácido Hialurónico En Defectos Perimplantares y Periodontales. Análisis de Una Serie de Casos Gingival Increase Based on Hyaluronic Acid in Peri Implant and Periodontal Defects. A Case Series Analysis . Int. J. Odontostomat vol. 11 (2017).
45. Dupont, L., de Souza, D. D. R. & Manzoni, A. P. D. Myomodulation with hyaluronic acid for correction of gummy smile. Surgical and Cosmetic Dermatology 13 , (2021).
46. Pires, Y. S. & Ribeiro, P. M. C. Orofacial Harmonization and the Use of Hyaluronic Acid and Botulinic Toxin: The Power to Restore Self - Esteem. ID on line REVISTA DE PSICOLOGIA 15 , 252 – 260 (2021).
47. Lambros, V. A technique for filling the temples with highly diluted hyaluronic acid: The ‘dilution solution’. Aesthet Surg J 31 , 89 – 94 (2011).
48. Trignano, E., Rusciani, A., Armenti, A. F., Corrias, F. & Fallico, N. Augmentation Mammaplasty after Breast Enhancement with Hyaluronic Acid. Aesthetic Surgery Journal vol. 35 NP161 – NP168 Preprint at https://doi.org/10.1093/asj/sjv042 (2015).
49. Fasola, E. & Gazzola, R. Labia Majora Augmentation with Hyaluronic Acid Filler: Technique and Results. Aesthet Surg J 36 , 1155 – 1163 (2016).
50. Zaccaro, C. et al. History and future perspectives of male aesthetic genital surgery. International Journal of Impotence Research vol. 34 327 – 331 Preprint at https://doi.org/10.1038/s41443 - 022 - 00580 - 6 (2022).
51. Aparecida, D. et al. Aesthetic Breast Augmentation with Hyaluronic Acid: Imaging Findings and Implications for Radiological Assessment . Fellow Master Degree in Health Sciences vol. 45 (2012).
52. Manfredi, C., Romero Otero, J. & Djinovic, R. Penile girth enhancement procedures for aesthetic purposes. International Journal of Impotence Research vol. 34 337 – 342 Preprint at https://doi.org/10.1038/s41443 - 021 - 00459 - y (2022).
53. Ahn, S. T., Il Kwak , T., Park, K. S., Kim, J. J. & Moon, D. G. Complications of glans penis augmentation. International Journal of Impotence Research vol. 31 245 – 255 Preprint at https://doi.org/10.1038/s41443 - 018 - 0097 - 4 (2019).
54. Pang, K. H. et al. Complications and outcomes following injection of foreign material into the male external genitalia for augmentation: a single - centre experience and systematic review. Int J Impot Res (2023) doi:10.1038/s41443 - 023 - 00675 - 8.
55. INVIMA. Recomendaciones para el uso seguro de dispositivos medicos. Instituto Nacional de Vigilancia de Medicamentos y Alimentos (2005).
56. INVIMA. Direccion de cosmeticos, aseo, plaguicidas y productos de higiene domestica: Guia de tramites. Instituto Nacional de Vigilancia de Medicamentos y Alimentos (2024).
57. INVIMA. Ácido Hialurónico para Rellenos Estéticos. Instituto Nacional de Vigilancia de Medicamentos y Alimentos (2015).
58. Ni, C. et al. Hyaluronic acid and HA - modified cationic liposomes for promoting skin penetration and retention. Journal of Controlled Release 357 , 432 – 443 (2023).
59. Reyes, R. et al. Skin penetration of caffeine from commercial eye creams and eye creams designed and optimized based on Hansen solubility parameters. Int J Pharm 639 , (2023).
60. Castaño Amores, C. & Hernández Benavides, P. J. Activos antioxidantes en la formulación de productos cosméticos antienvejecimiento. Ars Pharmaceutica (Internet) 59 , (2018).
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dc.publisher.faculty.none.fl_str_mv Barberi de Ingeniería, Diseño y Ciencias Aplicadas
dc.publisher.program.none.fl_str_mv Química Farmacéutica
dc.publisher.place.none.fl_str_mv Santiago de cali
publisher.none.fl_str_mv Universidad Icesi
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spelling Velásquez García, NataliaCastillo Bravo, Gabriela82c64e62-7a94-4d25-a9ee-be3885ee564a-1Cali de Lat: 03 24 00 N degrees minutes Lat: 3.4000 decimal degrees Long: 076 30 00 W degrees minutes Long: -76.5000 decimal degrees.2025-06-13T16:49:59Z2025-06-13T16:49:59Z2024-12-12https://hdl.handle.net/10906/130349https://biblioteca2.icesi.edu.co/cgi-olib/?oid=365030instname:Universidad Icesireponame:Biblioteca Digitalrepourl:https://repository.icesi.edu.co/This project aimed at the exhaustive compilation and consolidation of information on the cosmetic and aesthetic applications of hyaluronic acid in America and Europe during the last two decades. Its versatility, ability to provide volume, and maintain skin hydration have boosted its use as the most popular injectable filler in aesthetic medicine, covering a wide range of applications as topical products and facial and body dermal fillers. Through the review of databases such as Nature, Science Direct, Latindex, Oxford Academic, and Sage Journals, 7863 articles were collected, from which 60 were selected, meeting the required selection criteria. The information obtained was classified into general categories covering the lower third, middle third, upper third, body, comprehensive facial treatment, topical application, and complementary articles. This allowed addressing the generalities, applications, safety profiles, benefits, and potential complications of hyaluronic acid use. The reviewed studies confirm that hyaluronic acid offers a non-invasive alternative to traditional surgical methods, with reduced recovery times and adaptability to the anatomical characteristics of each patient. Regarding complications, it was found that, despite its high safety profile, mild complications such as swelling, bruising, and redness have been reported, as well as some more serious ones like vascular occlusions, granulomas, and infections which, although rare, require attention to prevent or treat them promptly.Este proyecto tuvo como fin la recopilación exhaustiva y consolidación de información sobre las aplicaciones cosméticas y estéticas del ácido hialurónico en América y Europa durante las últimas dos décadas. Su versatilidad, capacidad para aportar volumen y mantener la hidratación de la piel ha impulsado su uso como el relleno inyectable más popular en medicina estética, abarcando una amplia gama de aplicaciones como productos tópicos y rellenos dérmicos faciales y corporales. Mediante la revisión de bases de datos como Nature, Science Direct, Latindex, Oxford Academic y Sage Journals, se recopilaron 7863 artículos, de los cuales se seleccionaron 60, que cumplían con los criterios de selección requeridos. Clasificando la información obtenida en categorías generales que abarcaban tercio inferior, tercio medio, tercio superior, corporal, tratamiento integral del rostro, aplicación tópica y artículos complementarios. Permitiendo así abordar las generalidades, aplicaciones, perfiles de seguridad, beneficios y posibles complicaciones del uso del ácido hialurónico. Los estudios revisados confirman que el ácido hialurónico ofrece una alternativa no invasiva a los métodos quirúrgicos tradicionales, con tiempos reducidos de recuperación y adaptabilidad a las características anatómicas de cada paciente. Respecto a las complicaciones se encontró que, a pesar de su alto perfil de seguridad, se han reportado complicaciones leves como hinchazón, moretones y enrojecimiento, así como algunas más graves como oclusiones vasculares, granulomas e infecciones que, aunque poco frecuentes, requieren atención para prevenirlas o tratarlas oportunamente.Trabajo de Grado para obtener el título del Programa de Química FarmacéuticaProfesional54 páginasDigitalapplication/pdfspaUniversidad IcesiBarberi de Ingeniería, Diseño y Ciencias AplicadasQuímica FarmacéuticaSantiago de caliEL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos Todo persona que consulte ya sea la biblioteca o en medio electróico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autohttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://purl.org/coar/access_right/c_abf2Aplicaciones cosméticas y estéticas del ácido hialurónicobachelor thesishttp://purl.org/coar/resource_type/c_7a1fTrabajo de gradoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/bachelorThesisTodo PúblicoÁcido hialurónicoCosméticaEstéticaRelleno de tejidos blandosRelleno dérmicoTrabajo de grado de Química FarmacéuticaHyaluronic acidCosmeticsAestheticsSoft tissue fillerDermal filler1. 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Biotechnology for the Production of Chemicals, Intermediates, and Pharmaceutical Ingredients . (2016).7. Hyaluronic Acid. Thieme Medical Publishers 665 – 666 (2009).8. Pires Viana, G. André. H. O. Midori. C. A. Júlio. W. D. Renato. H. O. T. Treatment With Hyaluronic Acid Fillers . vol. 23 www.cosderm.com (2010).9. Crowley, E., Dalton, M. & Burke, G. Cytotoxicity and biocompatibility of bioresorbable polymers. in Bioresorbable Polymers: Biomedical Applications 101 – 120 (De Gruyter, 2019). doi:10.1515/9783110640571 - 006.10. Antonio, C. R. & Trídico, L. A. The importance of interaction between hyaluronic acid and CD44 receptor. Surgical and Cosmetic Dermatology 13 , (2021).11. Scardovi, S., Goglian, A., Gendra, P. & Gendra, C. Estudio clínico de eficacia, duración y efectos adversos del implante de Ácido Hialurónico en el área Buco - Maxilo - Facial Clinical study of the efficacy, duration and adverse effects of Hyaluronic Acid implants in the Oral - Maxillofacial area. 30 (2017) doi:10.22592/o2017n30a9.12. Hermans, A. M. Lifting, sculpting, and contouring: Implications of the blurred boundary between cosmetic procedures and ‘other’ beauty products/services. Poetics 90 , (2022).13. Sánchez - Carpintero, I., Candelas, D. & Ruiz - Rodríguez, R. Dermal Fillers: Types, Indications, and Complications. Actas Dermo - Sifiliográficas (English Edition) 101 , 381 – 393 (2010).14. Zhao, F., Chen, Y., He, D., You, X. & Xu, Y. Disastrous cerebral and ocular vascular complications after cosmetic facial filler injections: a retrospective case series study. Sci Rep 14 , (2024).15. FDA. FDA Dermal Fillers. (2024).16. FDA. FDA Approved Dermal Fillers. (2024).17. Frisina, A. C., Barbosa, B. de O., Teixeira, G. H. D. C. & Fernandes, R. L. Nasal reshaping with hyaluronic acid: Technique, risks, and benefits. Revista Brasileira de Cirurgia Plastica 36 , 108 – 114 (2021).18. Lipko - Godlewska, S. et al. Whole - face approach with hyaluronic acid fillers. Clinical, Cosmetic and Investigational Dermatology vol. 14 169 – 178 Preprint at https://doi.org/10.2147/CCID.S292501 (2021).19. Wypych, G. Functional Fillers: Applications: Soft Tissue - fillers. ChemTec Publishing 249 – 251 (2023).20. Bertossi, D. et al. Nonsurgical Redefinition of the Chin and Jawline of Younger Adults with a Hyaluronic Acid Filler: Results Evaluated with a Grid System Approach. Aesthet Surg J 41 , 1068 – 1076 (2021).21. Mahmood Faris, B. J. The Use of Facial Fillers in Clinical Practice: The Level of Patient Satisfaction and an Overview of Common Clinical Complications. Actas Dermosifiliogr 115 , 458 – 465 (2024).22. Cavallini, M., Gazzola, R., Metalla, M. & Vaienti, L. The role of hyaluronidase in the treatment of complications from hyaluronic acid dermal fillers. Aesthetic Surgery Journal vol. 33 1167 – 1174 Preprint at https://doi.org/10.1177/1090820X13511970 (2013).23. Sue, G. R., Seither, J. G. & Nguyen, D. H. Use of hyaluronic acid filler for enhancement of nipple projection following breast reconstruction: An easy and effective technique. JPRAS Open 23 , 19 – 25 (2020).24. Ordynowski, L. Cross - Linked Hyaluronic Acid for Cleft Lip and Palate Aesthetic Correction: A Preliminary Report. Aesthet Surg J Open Forum 4 , (2022).25. Biesman, B. S. et al. A Multicenter, Randomized, Evaluator - Blinded Study to Examine the Safety and Effectiveness of Hyaluronic Acid Filler in the Correction of Infraorbital Hollows. Aesthet Surg J (2024) doi:10.1093/asj/sjae073.26. Lambros, V. Volumizing the brow with hyaluronic acid fillers. Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery 29 , 174 – 179 (2009).27. Hedén, P. & Sinna, R. An open, prospective study to evaluate the effectiveness and safety of hyaluronic acid for pectus excavatum treatment. Aesthet Surg J 39 , NP189 – NP201 (2018).28. Colbert, S. D., Southorn, B. J., Brennan, P. A. & Ilankovan, V. Perils of dermal fillers. Br Dent J 214 , 339 – 340 (2013).29. Germani, M., Alegria, P., Giro, G. & Munoz - Lora, V. R. M. High - dose pulsed hyaluronidase for managing nasal skin necrosis following hyaluronic acid treatment in nasolabial folds: A case report. J Oral Biol Craniofac Res 14 , 339 – 341 (2024).30. Soares, D. J. & Zuliani, G. F. Orbital post - septal hyaluronic acid: An iatrogenic etiology compounding lower eyelid steatoblepharon. JPRAS Open 34 , 173 – 177 (2022).31. Szwed, M., Szwed, W., Szwed, J. & Miga, N. HA (hyaluronic acid) fillers in aesthetic medicine - the most common complications. Journal of Education, Health and Sport 12 , 722 – 729 (2022).32. Di Santis, É. P., Yarak, S., Martins, M. R. & Hirata, S. H. Compulsory notification of injuries in aesthetic procedures. Impact on patient safety. An Bras Dermatol 97 , 491 – 497 (2022).33. de Queiroz Hernandez, P. M. et al. Evaluation of the attractiveness of lips with different volumes after filling with hyaluronic acid. Sci Rep 13 , (2023).34. Rivkin, A. et al. Safe and Effective Restoration of Jawline Definition With Hyaluronic Acid Injectable Gel 4 VYC - 25L: Results From a Randomized Controlled Study. COSMETIC MEDICINE (2024) doi:10.1093/asj/sjae147/7710605.35. Alhallak, K., Omran, D. & Tomi, S. Achieving Bratz Doll Look with Lip Fillers: A Prospective Observational Study on Blunt Cannula Techniques. Plast Reconstr Surg Glob Open 12 , E5731 (2024).36. Swallow, M., Elgash, M., Kim, S. R., Hinchcliff, M. & Suozzi, K. Hyaluronic acid filler for lip augmentation in patients with systemic sclerosis: A prospective cohort study. JAAD Case Rep 49 , 79 – 81 (2024).37. Serge A. Steenen, C. G. B. B. van der L. N. S. M. van E. R. A. - S. W. K. T. J. 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Ars Pharmaceutica (Internet) 59 , (2018).ORIGINALTG04027.pdfTG04027.pdfapplication/pdf1295969https://repository.icesi.edu.co/bitstreams/a352a0d4-c613-4692-b70a-cc46913c31ad/downloada748d5af619d609d70e8f03ae4eb5791MD51LICENSElicense.txtlicense.txttext/plain1748https://repository.icesi.edu.co/bitstreams/f7639eba-bef3-4fba-9d9c-bc6b702c33f0/downloadbb9bdc0b3349e4284e09149f943790b4MD52CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8899https://repository.icesi.edu.co/bitstreams/d336a221-6848-4101-b182-5218944711c3/download3b6ce8e9e36c89875e8cf39962fe8920MD53THUMBNAILTG04027.pdf.jpgTG04027.pdf.jpgIM Thumbnailimage/jpeg5336https://repository.icesi.edu.co/bitstreams/0dcf6e18-1a60-4374-91dc-f6a690db961b/download5b458af91e7d943e252b18791a0e90d1MD5410906/130349oai:repository.icesi.edu.co:10906/1303492025-07-04 10:54:53.423http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalopen.accesshttps://repository.icesi.edu.coBiblioteca Digital - Universidad Icesiadquisicion-bib@listas.icesi.edu.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