Evaluación de bases orgánicas para la síntesis de ácido cannabidiólico a partir de cannabidiol

In this research project, the effect of different organic bases and cocatalysts on the synthesis of cannabidiolic acid (CBDA) from cannabidiol (CBD) was evaluated, with the aim of optimizing the reaction yield. The bases used, such as (1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), potassium t-butoxide (t-BuOK), and an inorganic base such as sodium hydride (NaH), along with metals such as magnesium, zinc, and nickel, achieved yields between 7.3% and 2.5%. Although these results did not significantly surpass those reported in previous studies, the need arises to optimize the process.

• Autores: Silva Mafla, Julian Andrés
• Tipo de recurso: Trabajo de grado de pregrado
• Fecha de publicación: 2024
• Institución: Universidad ICESI
• Repositorio: Repositorio ICESI
• Idioma: spa
• OAI Identifier: oai:repository.icesi.edu.co:10906/130364
• Acceso en línea: https://hdl.handle.net/10906/130364; https://biblioteca2.icesi.edu.co/cgi-olib/?oid=365038
• Palabra clave: Acido cannabidiólico (CBDA); Carboxilación; Dióxido de carbono; Dbu; Trabajo de grado de Química Farmacéutica; Cannabidiolic acid (CBDA); Carboxylation; Carbon dioxide; Dbu
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/4.0/