The polygenic implication of clopidogrel responsiveness: Insights from platelet reactivity analysis and next-generation sequencing

Clopidogrel is widely used worldwide as an antiplatelet therapy in patients with acute coronary disease. Genetic factors influence interindividual variability in response. Some studies have explored the polygenic contributions in the drug response, generating pharmacogenomic risk scores (PgxPRS). Im...

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Autores:
Tipo de recurso:
Fecha de publicación:
2024
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/44844
Acceso en línea:
https://doi.org/10.1371/journal.pone.0306445
https://repository.urosario.edu.co/handle/10336/44844
Palabra clave:
Clopidogrel
Antiplatelet therapy
Rights
License
Attribution-NonCommercial-NoDerivatives 4.0 International
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oai_identifier_str oai:repository.urosario.edu.co:10336/44844
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv The polygenic implication of clopidogrel responsiveness: Insights from platelet reactivity analysis and next-generation sequencing
title The polygenic implication of clopidogrel responsiveness: Insights from platelet reactivity analysis and next-generation sequencing
spellingShingle The polygenic implication of clopidogrel responsiveness: Insights from platelet reactivity analysis and next-generation sequencing
Clopidogrel
Antiplatelet therapy
title_short The polygenic implication of clopidogrel responsiveness: Insights from platelet reactivity analysis and next-generation sequencing
title_full The polygenic implication of clopidogrel responsiveness: Insights from platelet reactivity analysis and next-generation sequencing
title_fullStr The polygenic implication of clopidogrel responsiveness: Insights from platelet reactivity analysis and next-generation sequencing
title_full_unstemmed The polygenic implication of clopidogrel responsiveness: Insights from platelet reactivity analysis and next-generation sequencing
title_sort The polygenic implication of clopidogrel responsiveness: Insights from platelet reactivity analysis and next-generation sequencing
dc.subject.spa.fl_str_mv Clopidogrel
Antiplatelet therapy
topic Clopidogrel
Antiplatelet therapy
description Clopidogrel is widely used worldwide as an antiplatelet therapy in patients with acute coronary disease. Genetic factors influence interindividual variability in response. Some studies have explored the polygenic contributions in the drug response, generating pharmacogenomic risk scores (PgxPRS). Importantly, these factors are less explored in underrepresented populations, such as Latin-American countries. Identifying patients at risk of high-on-treatment platelet reactivity (HTPR) is highly valuable in translational medicine. In this study we used a custom next-generation sequencing (NGS) panel composed of 91 single nucleotide polymorphisms (SNPs) and 28 genes related to clopidogrel metabolism, to analyze 70 patients with platelet reactivity values, assessed through closure time (CT). Our results demonstrated the association of SNPs with HTPR and non-HTPR, revealing the strongest associations with rs2286823 (OR: 5,0
publishDate 2024
dc.date.created.spa.fl_str_mv 2024-07-01
dc.date.issued.spa.fl_str_mv 2024-07-01
dc.date.accessioned.none.fl_str_mv 2025-01-26T18:36:54Z
dc.date.available.none.fl_str_mv 2025-01-26T18:36:54Z
dc.type.spa.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1371/journal.pone.0306445
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/44844
url https://doi.org/10.1371/journal.pone.0306445
https://repository.urosario.edu.co/handle/10336/44844
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartof.spa.fl_str_mv PLOS ONE
dc.rights.spa.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
Abierto (Texto Completo)
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dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv PLOS ONE
dc.source.spa.fl_str_mv PLOS ONE
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
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