Unveiling the pathogenic mechanisms of Clostridium perfringens toxins and virulence factors

Clostridium perfringens causes multiple diseases in humans and animals. Its pathogenic effect is supported by a broad and heterogeneous arsenal of toxins and other virulence factors associated with a specific host tropism. Molecular approaches have indicated that most C. perfringens toxins produce m...

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Autores:
Tipo de recurso:
Fecha de publicación:
2024
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/44848
Acceso en línea:
https://doi.org/10.1080/22221751.2024.2341968
https://repository.urosario.edu.co/handle/10336/44848
Palabra clave:
Clostridium perfringens
toxin type
enteritis
genetic diversity
host
toxinotypes.
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License
Attribution-NonCommercial-NoDerivatives 4.0 International
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spelling 8b2f9046-3565-430c-9e2e-595e52f459941011716118600ce235112-36c7-4a21-8cfa-3c5faa0ae59d6fe04044-d38e-4b52-bcf1-8f51fe683f747dac049d-c747-4b91-849c-c2efae4da8242025-01-26T18:37:14Z2025-01-26T18:37:14Z2024-12-012024-12-01Clostridium perfringens causes multiple diseases in humans and animals. Its pathogenic effect is supported by a broad and heterogeneous arsenal of toxins and other virulence factors associated with a specific host tropism. Molecular approaches have indicated that most C. perfringens toxins produce membrane pores, leading to osmotic cell disruption and apoptosis. However, identifying mechanisms involved in cell tropism and selective toxicity effects should be studied more. The differential presence and polymorphisms of toxin-encoding genes and genes encoding other virulence factors suggest that molecular mechanisms might exist associated with host preference, receptor binding, and impact on the hosthowever, this information has not been reviewed in detail. Therefore, this review aims to clarify the current state of knowledge on the structural features and mechanisms of action of the major toxins and virulence factors of C. perfringens and discuss the impact of genetic diversity of toxinotypes in tropism for several hosts.application/pdfhttps://doi.org/10.1080/22221751.2024.2341968https://repository.urosario.edu.co/handle/10336/44848engEmerging Microbes and InfectionsEmerging Microbes and InfectionsAttribution-NonCommercial-NoDerivatives 4.0 InternationalAbierto (Texto Completo)http://creativecommons.org/licenses/by-nc-sa/4.0/http://purl.org/coar/access_right/c_abf2Emerging Microbes and Infectionsinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURClostridium perfringenstoxin typeenteritisgenetic diversityhosttoxinotypes.Unveiling the pathogenic mechanisms of Clostridium perfringens toxins and virulence factorsarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Camargo, ARamírez González, Juan DavidKiu, RHall LJMuñoz, MarinaORIGINALUnveiling_the_pathogenic_mechanisms_of_Clostridium.pdfapplication/pdf1871812https://repository.urosario.edu.co/bitstreams/6320b3d1-4785-4520-b511-a0806959d13e/downloadde3359e6744b294cb55459b25f4a25fbMD51TEXTUnveiling_the_pathogenic_mechanisms_of_Clostridium.pdf.txtUnveiling_the_pathogenic_mechanisms_of_Clostridium.pdf.txtExtracted texttext/plain59416https://repository.urosario.edu.co/bitstreams/e4855560-de95-47e7-b53c-0bb9936b5340/download0551a3c5a26d2e8c9781a8734a627055MD52THUMBNAILUnveiling_the_pathogenic_mechanisms_of_Clostridium.pdf.jpgUnveiling_the_pathogenic_mechanisms_of_Clostridium.pdf.jpgGenerated Thumbnailimage/jpeg5164https://repository.urosario.edu.co/bitstreams/ee35c307-e7e5-403b-b252-010333082dde/downloadb4c96aed4b548a77ca1e454cad7c4a1bMD5310336/44848oai:repository.urosario.edu.co:10336/448482025-01-27 03:01:56.043http://creativecommons.org/licenses/by-nc-sa/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttps://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Unveiling the pathogenic mechanisms of Clostridium perfringens toxins and virulence factors
title Unveiling the pathogenic mechanisms of Clostridium perfringens toxins and virulence factors
spellingShingle Unveiling the pathogenic mechanisms of Clostridium perfringens toxins and virulence factors
Clostridium perfringens
toxin type
enteritis
genetic diversity
host
toxinotypes.
title_short Unveiling the pathogenic mechanisms of Clostridium perfringens toxins and virulence factors
title_full Unveiling the pathogenic mechanisms of Clostridium perfringens toxins and virulence factors
title_fullStr Unveiling the pathogenic mechanisms of Clostridium perfringens toxins and virulence factors
title_full_unstemmed Unveiling the pathogenic mechanisms of Clostridium perfringens toxins and virulence factors
title_sort Unveiling the pathogenic mechanisms of Clostridium perfringens toxins and virulence factors
dc.subject.spa.fl_str_mv Clostridium perfringens
toxin type
enteritis
genetic diversity
host
toxinotypes.
topic Clostridium perfringens
toxin type
enteritis
genetic diversity
host
toxinotypes.
description Clostridium perfringens causes multiple diseases in humans and animals. Its pathogenic effect is supported by a broad and heterogeneous arsenal of toxins and other virulence factors associated with a specific host tropism. Molecular approaches have indicated that most C. perfringens toxins produce membrane pores, leading to osmotic cell disruption and apoptosis. However, identifying mechanisms involved in cell tropism and selective toxicity effects should be studied more. The differential presence and polymorphisms of toxin-encoding genes and genes encoding other virulence factors suggest that molecular mechanisms might exist associated with host preference, receptor binding, and impact on the host
publishDate 2024
dc.date.created.spa.fl_str_mv 2024-12-01
dc.date.issued.spa.fl_str_mv 2024-12-01
dc.date.accessioned.none.fl_str_mv 2025-01-26T18:37:14Z
dc.date.available.none.fl_str_mv 2025-01-26T18:37:14Z
dc.type.spa.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1080/22221751.2024.2341968
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/44848
url https://doi.org/10.1080/22221751.2024.2341968
https://repository.urosario.edu.co/handle/10336/44848
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartof.spa.fl_str_mv Emerging Microbes and Infections
dc.rights.spa.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
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dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
Abierto (Texto Completo)
http://creativecommons.org/licenses/by-nc-sa/4.0/
http://purl.org/coar/access_right/c_abf2
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dc.publisher.spa.fl_str_mv Emerging Microbes and Infections
dc.source.spa.fl_str_mv Emerging Microbes and Infections
institution Universidad del Rosario
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dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
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