Effect of social instability on social recognition and partner preference in guinea pigs, Cavia porcellus

La inestabilidad social desencadena diversas respuestas fisiológicas y endocrinológicas al estrés. Las fluctuaciones hormonales inducidas por el estrés y reguladas por el eje HPA modulan los procesos sociales y de memoria. En este estudio, evalué el efecto de la inestabilidad social sobre la prefere...

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Fecha de publicación:: 2025

Institución:: Universidad del Rosario

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network_name_str	Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.none.fl_str_mv	Effect of social instability on social recognition and partner preference in guinea pigs, Cavia porcellus
dc.title.TranslatedTitle.none.fl_str_mv	Efecto de la inestabilidad social en el reconocimiento social y la preferencia por compañero en cuyes, Cavia porcellus
title	Effect of social instability on social recognition and partner preference in guinea pigs, Cavia porcellus
spellingShingle	Effect of social instability on social recognition and partner preference in guinea pigs, Cavia porcellus Cambios en la composición de grupo Cortisol Eje HPA Mecanismos endocrinológicos Organización social Oxitocina Endocrinological mechanisms Changes in group composition Cortisol HPA-axis Oxytocin Social organization
title_short	Effect of social instability on social recognition and partner preference in guinea pigs, Cavia porcellus
title_full	Effect of social instability on social recognition and partner preference in guinea pigs, Cavia porcellus
title_fullStr	Effect of social instability on social recognition and partner preference in guinea pigs, Cavia porcellus
title_full_unstemmed	Effect of social instability on social recognition and partner preference in guinea pigs, Cavia porcellus
title_sort	Effect of social instability on social recognition and partner preference in guinea pigs, Cavia porcellus
dc.contributor.advisor.none.fl_str_mv	Maldonado Chaparro, Adriana Alexandra
dc.subject.none.fl_str_mv	Cambios en la composición de grupo Cortisol Eje HPA Mecanismos endocrinológicos Organización social Oxitocina
topic	Cambios en la composición de grupo Cortisol Eje HPA Mecanismos endocrinológicos Organización social Oxitocina Endocrinological mechanisms Changes in group composition Cortisol HPA-axis Oxytocin Social organization
dc.subject.keyword.none.fl_str_mv	Endocrinological mechanisms Changes in group composition Cortisol HPA-axis Oxytocin Social organization
description	La inestabilidad social desencadena diversas respuestas fisiológicas y endocrinológicas al estrés. Las fluctuaciones hormonales inducidas por el estrés y reguladas por el eje HPA modulan los procesos sociales y de memoria. En este estudio, evalué el efecto de la inestabilidad social sobre la preferencia y el reconocimiento social en cobayas (Cavia porcellus) y medí los niveles de cortisol (CORT) y oxitocina (OT) en sangre. Mis resultados mostraron que la inestabilidad social afecta a la preferencia social, pero no afectó significativamente al reconocimiento social ni a los niveles de CORT u OT. Estos resultados sugieren que la inestabilidad social afecta a los procesos sociales, como los procesos de toma de decisiones sociales, independientemente de los cambios inmediatos en CORT y OT circulantes, contribuyendo a nuestra comprensión de la interacción entre el estrés social y el comportamiento social.
publishDate	2025
dc.date.accessioned.none.fl_str_mv	2025-05-15T13:39:00Z
dc.date.available.none.fl_str_mv	2025-05-15T13:39:00Z
dc.date.created.none.fl_str_mv	2025-04-23
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dc.type.none.fl_str_mv	bachelorThesis
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_7a1f
dc.type.spa.none.fl_str_mv	Trabajo de grado
dc.identifier.uri.none.fl_str_mv	https://repository.urosario.edu.co/handle/10336/45328
url	https://repository.urosario.edu.co/handle/10336/45328
dc.language.iso.none.fl_str_mv	eng
language	eng
dc.rights.*.fl_str_mv	Attribution-NonCommercial-ShareAlike 4.0 International
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rights_invalid_str_mv	Attribution-NonCommercial-ShareAlike 4.0 International Restringido (Temporalmente bloqueado) http://creativecommons.org/licenses/by-nc-sa/4.0/ http://purl.org/coar/access_right/c_f1cf
dc.format.extent.none.fl_str_mv	36 pp
dc.format.mimetype.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Universidad del Rosario
dc.publisher.department.none.fl_str_mv	Facultad de Ciencias Naturales
dc.publisher.program.none.fl_str_mv	Biología
publisher.none.fl_str_mv	Universidad del Rosario
institution	Universidad del Rosario
dc.source.bibliographicCitation.none.fl_str_mv	Baranyi, J., Bakos, N., & Haller, J. (2005). Social instability in female rats: The relationship between stress-related and anxiety-like consequences. Physiology & Behavior, 84(4), 511-518. https://doi.org/10.1016/j.physbeh.2005.01.005 Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011). Social effects of oxytocin in humans: Context and person matter. Trends in Cognitive Sciences, 15(7), 301-309. https://doi.org/10.1016/j.tics.2011.05.002 Bates, D., Mächler, M., Bolker, B., & Walker, S. (2015). Fitting Linear Mixed-Effects Models Using lme4. Journal of Statistical Software, 67, 1-48. https://doi.org/10.18637/jss.v067.i01 Beery, A. K. (2015). Antisocial oxytocin: Complex effects on social behavior. Current Opinion in Behavioral Sciences, 6, 174-182. https://doi.org/10.1016/j.cobeha.2015.11.006 Beery, A. K., & Kaufer, D. (2015). Stress, social behavior, and resilience: Insights from rodents. Neurobiology of Stress, 1, 116-127. https://doi.org/10.1016/j.ynstr.2014.10.004 Beery, A. K., & Shambaugh, K. L. (2021). Comparative Assessment of Familiarity/Novelty Preferences in Rodents. Frontiers in Behavioral Neuroscience, 15. https://doi.org/10.3389/fnbeh.2021.648830 Beery, A. K., & Zucker, I. (2010). Oxytocin and same-sex social behavior in female meadow voles. Neuroscience, 169(2), 665-673. https://doi.org/10.1016/j.neuroscience.2010.05.023 Bielsky, I. F., & Young, L. J. (2004). Oxytocin, vasopressin, and social recognition in mammals. Peptides, 25(9), 1565-1574. https://doi.org/10.1016/j.peptides.2004.05.019 Bókony, V., Lendvai, A. Z., Liker, A., Angelier, F., Wingfield, J. C., & Chastel, O. (2009). Stress response and the value of reproduction: Are birds prudent parents? The American Naturalist, 173(5), 589-598. https://doi.org/10.1086/597610 Cabeza, L., Ramadan, B., Giustiniani, J., Houdayer, C., Pellequer, Y., Gabriel, D., Fauconnet, S., Haffen, E., Risold, P.-Y., Fellmann, D., Belin, D., & Peterschmitt, Y. (2021). Chronic exposure to glucocorticoids induces suboptimal decision-making in mice. European Neuropsychopharmacology, 46, 56-67. https://doi.org/10.1016/j.euroneuro.2021.01.094 Cheetham, S. A., Thom, M. D., Beynon, R. J., & Hurst, J. L. (2008). The Effect of Familiarity on Mate Choice. En J. L. Hurst, R. J. Beynon, S. C. Roberts, & T. D. Wyatt (Eds.), Chemical Signals in Vertebrates 11 (pp. 271-280). Springer. https://doi.org/10.1007/978-0-387-73945-8_26 Cohen, S., Janicki-Deverts, D., Doyle, W. J., Miller, G. E., Frank, E., Rabin, B. S., & Turner, R. B. (2012). Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proceedings of the National Academy of Sciences, 109(16), 5995-5999. https://doi.org/10.1073/pnas.1118355109 Cruz-Topete, D., & Cidlowski, J. A. (2015). One hormone, two actions: Anti- and pro-inflammatory effects of glucocorticoids. Neuroimmunomodulation, 22(1-2), 20-32. https://doi.org/10.1159/000362724 Declerck, C. H., Boone, C., & Kiyonari, T. (2010). Oxytocin and cooperation under conditions of uncertainty: The modulating role of incentives and social information. Hormones and Behavior, 57(3), 368-374. https://doi.org/10.1016/j.yhbeh.2010.01.006 Donatti, T. L., Koch, V. H. K., Takayama, L., & Pereira, R. M. R. (2011). Effects of glucocorticoids on growth and bone mineralization. Jornal De Pediatria, 87(1), 4-12. https://doi.org/10.2223/JPED.2052 Ferguson, J. N., Young, L. J., & Insel, T. R. (2002). The Neuroendocrine Basis of Social Recognition. Frontiers in Neuroendocrinology, 23(2), 200-224. https://doi.org/10.1006/frne.2002.0229 Friard, O., & Gamba, M. (2016). BORIS: A free, versatile open-source event-logging software for video/audio coding and live observations. Methods in Ecology and Evolution, 7(11), 1325 1330. https://doi.org/10.1111/2041-210X.12584 Frith, C. D., & Singer, T. (2008). The role of social cognition in decision making. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(1511), 3875-3886. https://doi.org/10.1098/rstb.2008.0156 Gao, W., Stalder, T., & Kirschbaum, C. (2015). Quantitative analysis of estradiol and six other steroid hormones in human saliva using a high throughput liquid chromatography-tandem mass spectrometry assay. Talanta, 143, 353-358. https://doi.org/10.1016/j.talanta.2015.05.004 Gheusi, G., Bluthé, R.-M., Goodall, G., & Dantzer, R. (1994). Social and individual recognition in rodents: Methodological aspects and neurobiological bases. Behavioural Processes, 33(1), 59-87. https://doi.org/10.1016/0376-6357(94)90060-4 Gibbs, D. M. (1986). 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Current hypertension reports, 14(6), 573-580. https://doi.org/10.1007/s11906-012-0297-0 Heinrichs, M., Meinlschmidt, G., Wippich, W., Ehlert, U., & Hellhammer, D. H. (2004). Selective amnesic effects of oxytocin on human memory. Physiology & Behavior, 83(1), 31-38. https://doi.org/10.1016/j.physbeh.2004.07.020 Hodges, T. E., Baumbach, J. L., Marcolin, M. L., Bredewold, R., Veenema, A. H., & McCormick, C. M. (2017). Social instability stress in adolescent male rats reduces social interaction and social recognition performance and increases oxytocin receptor binding. Neuroscience, 359, 172 182. https://doi.org/10.1016/j.neuroscience.2017.07.032 Joëls, M. (2011). Impact of glucocorticoids on brain function: Relevance for mood disorders. Psychoneuroendocrinology, 36(3), 406-414. https://doi.org/10.1016/j.psyneuen.2010.03.004 Keller, B. A., Finger, J.-S., Gruber, S. H., Abel, D. C., & Guttridge, T. L. (2017). The effects of familiarity on the social interactions of juvenile lemon sharks, Negaprion brevirostris. Journal of Experimental Marine Biology and Ecology, 489, 24-31. https://doi.org/10.1016/j.jembe.2017.01.004 Kuznetsova, A., Brockhoff, P. B., & Christensen, R. H. B. (2017). lmerTest Package: Tests in Linear Mixed Effects Models. Journal of Statistical Software, 82, 1-26. https://doi.org/10.18637/jss.v082.i13 Lenth, R. V. (2017). emmeans: Estimated Marginal Means, aka Least-Squares Means (p. 1.10.7) [Dataset]. https://doi.org/10.32614/CRAN.package.emmeans Liberzon, I., & Young, E. A. (1997). Effects of stress and glucocorticoids on CNS oxytocin receptor binding. Psychoneuroendocrinology, 22(6), 411-422. https://doi.org/10.1016/S0306 4530(97)00045-0 Light, K. C., Grewen, K. M., Amico, J. A., Boccia, M., Brownley, K. A., & Johns, J. M. (2004). Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancy. Addictive Behaviors, 29(8), 1541-1564. https://doi.org/10.1016/j.addbeh.2004.02.062 Linnen, A.-M., Ellenbogen, M. A., Cardoso, C., & Joober, R. (2012). Intranasal oxytocin and salivary cortisol concentrations during social rejection in university students. Stress, 15(4), 393 402. https://doi.org/10.3109/10253890.2011.631154 Nakayasu, T., & Kato, K. (2011). Is full physical contact necessary for buffering effects of pair housing on social stress in rats? Behavioural Processes, 86(2), 230-235. https://doi.org/10.1016/j.beproc.2010.12.002 Neumann, I. D., Torner, L., & Wigger, A. (1999). Brain oxytocin: Differential inhibition of neuroendocrine stress responses and anxiety-related behaviour in virgin, pregnant and lactating rats. Neuroscience, 95(2), 567-575. https://doi.org/10.1016/S0306 4522(99)00433-9 Parker, K. J., Buckmaster, C. L., Schatzberg, A. F., & Lyons, D. M. (2005). Intranasal oxytocin administration attenuates the ACTH stress response in monkeys. Psychoneuroendocrinology, 30(9), 924-929. https://doi.org/10.1016/j.psyneuen.2005.04.002 Patki, G., Solanki, N., Atrooz, F., Allam, F., & Salim, S. (2013). Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress. Brain Research, 1539, 73-86. https://doi.org/10.1016/j.brainres.2013.09.033 Petersson, M. (2002). Chapter 22 Cardiovascular effects of oxytocin. En Progress in Brain Research (Vol. 139, pp. 281-288). Elsevier. https://doi.org/10.1016/S0079-6123(02)39024-1 Putman, P., Antypa, N., Crysovergi, P., & van der Does, W. A. J. (2010). Exogenous cortisol acutely influences motivated decision making in healthy young men. Psychopharmacology, 208(2), 257-263. https://doi.org/10.1007/s00213-009-1725-y R Core Team. 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spelling	Maldonado Chaparro, Adriana Alexandra37861034600Pantoja Ruíz, ValentinaBiólogoPregrado9f03de59-2cb9-4fd7-8e8b-dda974492bba-12025-05-15T13:39:00Z2025-05-15T13:39:00Z2025-04-23info:eu-repo/date/embargoEnd/2027-05-16La inestabilidad social desencadena diversas respuestas fisiológicas y endocrinológicas al estrés. Las fluctuaciones hormonales inducidas por el estrés y reguladas por el eje HPA modulan los procesos sociales y de memoria. En este estudio, evalué el efecto de la inestabilidad social sobre la preferencia y el reconocimiento social en cobayas (Cavia porcellus) y medí los niveles de cortisol (CORT) y oxitocina (OT) en sangre. Mis resultados mostraron que la inestabilidad social afecta a la preferencia social, pero no afectó significativamente al reconocimiento social ni a los niveles de CORT u OT. Estos resultados sugieren que la inestabilidad social afecta a los procesos sociales, como los procesos de toma de decisiones sociales, independientemente de los cambios inmediatos en CORT y OT circulantes, contribuyendo a nuestra comprensión de la interacción entre el estrés social y el comportamiento social.Social instability triggers diverse physiological and endocrinological stress responses that can affect social decisions. Stress-induced hormonal fluctuations regulated by the HPA-axis modulate social and memory processes. In this study, I evaluated the effect of social instability on social preference and recognition in guinea pigs (Cavia porcellus), and measured blood cortisol (CORT) and oxytocin (OT) levels. My results showed that social instability affects social preference but did not significantly affect on social recognition or CORT or OT levels. These findings suggest that social instability affects social processes such as social decision-making processes, independently of immediate changes in circulating CORT and OT, contributing to our understanding of the interplay between social stress and social behavior.36 ppapplication/pdfhttps://repository.urosario.edu.co/handle/10336/45328engUniversidad del RosarioFacultad de Ciencias NaturalesBiologíaAttribution-NonCommercial-ShareAlike 4.0 InternationalRestringido (Temporalmente bloqueado)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.http://creativecommons.org/licenses/by-nc-sa/4.0/http://purl.org/coar/access_right/c_f1cfBaranyi, J., Bakos, N., & Haller, J. (2005). Social instability in female rats: The relationship between stress-related and anxiety-like consequences. Physiology & Behavior, 84(4), 511-518. https://doi.org/10.1016/j.physbeh.2005.01.005Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011). Social effects of oxytocin in humans: Context and person matter. Trends in Cognitive Sciences, 15(7), 301-309. https://doi.org/10.1016/j.tics.2011.05.002Bates, D., Mächler, M., Bolker, B., & Walker, S. (2015). Fitting Linear Mixed-Effects Models Using lme4. Journal of Statistical Software, 67, 1-48. https://doi.org/10.18637/jss.v067.i01Beery, A. K. (2015). Antisocial oxytocin: Complex effects on social behavior. Current Opinion in Behavioral Sciences, 6, 174-182. https://doi.org/10.1016/j.cobeha.2015.11.006Beery, A. K., & Kaufer, D. (2015). Stress, social behavior, and resilience: Insights from rodents. Neurobiology of Stress, 1, 116-127. https://doi.org/10.1016/j.ynstr.2014.10.004Beery, A. K., & Shambaugh, K. L. (2021). Comparative Assessment of Familiarity/Novelty Preferences in Rodents. 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Effect of social instability on social recognition and partner preference in guinea pigs, Cavia porcellus

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