16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus

Background: The 16/6-idiotype (16/6-Id) of the human anti-DNA antibody was found to induce experimental lupus in naive mice, manifested by production of autoantibodies, leukopenia and elevated inflammatory markers, as well as kidney and brain involvement. We assessed behavior and brain pathology of...

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Autores:

Tipo de recurso:

Fecha de publicación:

2013

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/8833

Acceso en línea:

http://repository.urosario.edu.co/handle/10336/8833

Palabra clave:

Enfermedades
Anticuerpos
Lupus eritematoso sistémico
Enfermedades autoinmunes
MONOCLONAL ANTI-DNA
TISSUE-BOUND IMMUNOGLOBULINS
HUMAN-HUMAN HYBRIDOMAS
P-PROTEINS PENETRATE
ANTIPHOSPHOLIPID SYNDROME
NEUROPSYCHIATRIC LUPUS
TOLEROGENIC PEPTIDE
RECOGNITION MEMORY
SLE PATIENTS
AUTOANTIBODIES

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