Thermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures
Se presenta el análisis termodinámico y la solvación preferencial de la solubilidad de la sulfanilamida (SA) en cinco mezclas de cosolventes (etanol + agua; 1,4-dioxano + agua, acetonitrilo + agua, dimetil-sulfuróxido + agua y dimetilsulfóxido + agua). Las funciones termodinámicas se calculan emplea...
- Autores:
-
Ortiz, Claudia
Cardenas, Rossember
Caviedes-Rubio, Diego Ivan
Polania-Orozco, Sebastian De Jesus
Delgado, Daniel Ricardo
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2021
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/46633
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/46633
- Palabra clave:
- Sulfanilamida
Termodinámica de soluciones
Kirkwood–Buff
Solvatación Preferencial
Q2
Sulphanilamide
solubilityt hermodynamic
Kirkwood–Buff
preferential solvation
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- embargoedAccess
- License
- Atribución – No comercial – Compartir igual
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| dc.title.spa.fl_str_mv |
Thermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures |
| title |
Thermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures |
| spellingShingle |
Thermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures Sulfanilamida Termodinámica de soluciones Kirkwood–Buff Solvatación Preferencial Q2 Sulphanilamide solubilityt hermodynamic Kirkwood–Buff preferential solvation |
| title_short |
Thermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures |
| title_full |
Thermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures |
| title_fullStr |
Thermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures |
| title_full_unstemmed |
Thermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures |
| title_sort |
Thermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures |
| dc.creator.fl_str_mv |
Ortiz, Claudia Cardenas, Rossember Caviedes-Rubio, Diego Ivan Polania-Orozco, Sebastian De Jesus Delgado, Daniel Ricardo |
| dc.contributor.advisor.none.fl_str_mv |
Delgado, Daniel Ricardo |
| dc.contributor.author.none.fl_str_mv |
Ortiz, Claudia Cardenas, Rossember Caviedes-Rubio, Diego Ivan Polania-Orozco, Sebastian De Jesus Delgado, Daniel Ricardo |
| dc.subject.spa.fl_str_mv |
Sulfanilamida Termodinámica de soluciones Kirkwood–Buff Solvatación Preferencial |
| topic |
Sulfanilamida Termodinámica de soluciones Kirkwood–Buff Solvatación Preferencial Q2 Sulphanilamide solubilityt hermodynamic Kirkwood–Buff preferential solvation |
| dc.subject.classification.spa.fl_str_mv |
Q2 |
| dc.subject.other.spa.fl_str_mv |
Sulphanilamide solubilityt hermodynamic Kirkwood–Buff preferential solvation |
| description |
Se presenta el análisis termodinámico y la solvación preferencial de la solubilidad de la sulfanilamida (SA) en cinco mezclas de cosolventes (etanol + agua; 1,4-dioxano + agua, acetonitrilo + agua, dimetil-sulfuróxido + agua y dimetilsulfóxido + agua). Las funciones termodinámicas se calculan empleando las ecuaciones de Gibbs y van ́t Hoff, y el análisis de la solvación preferencial se desarrolla mediante el método inverso de las integrales Kirkwood-Buff. El proceso de solubilidad es endotérmico, con favores entrópicos en todos los casos. Finalmente, de acuerdo con el parámetro de solvación, el SA se solva preferentemente con agua en mezclas más polares, y en las mezclas DMF + W y DMSO + W se solva con disolvente orgánico. En las otras mezclas (EtOH + W, DIOX + W y MeCN + W) el SA se solva por el disolvente orgánico en mezclas intermedias y por el agua en las mezclas menos polares. |
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2021 |
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2021-02-26 |
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2022-10-06T17:16:41Z |
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2022-10-06T17:16:41Z 2024-02-01 |
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Artículo |
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10.1080/00319104.2021.1888382 |
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https://hdl.handle.net/20.500.12494/46633 |
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Thermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures CP Ortíz, RE Cardenas-Torres, DI Caviedes-Rubio, SDJ Polania-Orozco, ... Physics and Chemistry of Liquids 60 (1), 9-24 |
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10290451 10.1080/00319104.2021.1888382 Thermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures CP Ortíz, RE Cardenas-Torres, DI Caviedes-Rubio, SDJ Polania-Orozco, ... Physics and Chemistry of Liquids 60 (1), 9-24 |
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https://www.tandfonline.com/doi/abs/10.1080/00319104.2021.1888382 |
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Physics and Chemistry of Liquids |
| dc.relation.references.spa.fl_str_mv |
Paulechka E, Kazakov A. ENTHALPY OF FORMATION OF AQUEOUS HYDROFLUORIC ACID: REVISION NEEDED? The Journal of Chemical Thermodynamics. 2020;142:106308. Du J, Xiao G, Xi Y, et al. Periodate activation with manganese oxides for sulfanilamide degradation. Water Res. 2020;169:115278. Blanco-Márquez JH, Quigua-Medina YA, García-Murillo JD, et al. Thermodynamic analysis and applications of the Abraham solvation parameter model in the study of the solubility of some sulfonamides. Rev Colomb Cienc Quím Farm. 2020;49(1):234–255. Delgado DR, Caviedes-Rubio DI, Ortiz CP, et al. Solubility of sulphadiazine in (acetonitrile + water) mixtures: measurement, correlation, thermodynamics and preferential solvation. Phys Chem Liq. 2020;58(3):381–396. Delgado DR, Martínez F. Solubility and preferential solvation of sulfadiazine in methanol+water mixtures at several temperatures. Fluid Phase Equilib. 2014;379:128–138. Blanco-Márquez JH, Caviedes Rubio DI, Ortiz CP, et al. Thermodynamic analysis and preferential solvation of sulfamethazine in acetonitrile + water cosolvent mixtures. Fluid Phase Equilib. 2020;505:112361. Blanco-Márquez JH, Ortiz CP, Cerquera NE, et al. Thermodynamic analysis of the solubility and preferential solvation of sulfamerazine in (acetonitrile + water) cosolvent mixtures at different temperatures. Journal of Molecular Liquids. 2019;293:111507. Delgado DR, Peña MA, Martínez F, et al. Further numerical analyses on the solubility of sulfapyridine in ethanol + water mixtures. Pharmaceutical Sciences. 2016;22(3):143–152. Delgado DR, Almanza OA, Martínez F, et al. Solution thermodynamics and preferential solvation of sulfamethazine in (methanol + water) mixtures. The Journal of Chemical Thermodynamics. 2016;97:264–276. Jiménez DM, Cárdenas ZJ, Delgado DR, et al. Solubility temperature dependence and preferential solvation of sulfadiazine in 1,4-dioxane+water co-solvent mixtures. Fluid Phase Equilib. 2015;397:26–36. Delgado DR, Martínez F. Preferential solvation of some structurally related sulfonamides in 1-propanol + water co-solvent mixtures. Physics and Chemistry of Liquids. 2015;53(3):293–306. Del Mar Muñoz M, Delgado DR, Peña MÁ, et al. Solubility and preferential solvation of sulfadiazine, sulfamerazine and sulfamethazine in propylene glycol+water mixtures at 298.15K. Journal of Molecular Liquids. 2015;204:132–136. Delgado DR, Martínez F. Solution thermodynamics and preferential solvation of sulfamerazine in methanol + water mixtures. J Solut Chem. 2015;44:360–377. Delgado DR, Rodríguez GA, Martínez F. Thermodynamic study of the solubility of sulfapyridine in some ethanol + water mixtures. J Mol Liq. 2013;177:156–161. Delgado DR, Peña MÁ, Martínez F. Preferential solvation of some sulfonamides in 1,4-dioxane + water co-solvent mixtures at 298.15 K according to the inverse Kirkwood-Buff integrals method. Rev Acad. Colomb. Cienc. Exact. Fis. Nat. Vol. 38. 2014. p. 104–114. Delgado DR, Jouyban A, Martínez F. Solubility and preferential solvation of meloxicam in methanol + water mixtures at 298.15 K. J Mol Liq. 2014;197:368–373. Romero-Nieto AM, Caviedes-Rubio DI, Polania-Orozco J, et al. Temperature and cosolvent composition effects in the solubility of methylparaben in acetonitrile + water mixtures. Phys Chem Liq. 2019. DOI:10.1080/ 00319104.2019.1636379 Delgado DR, Jouyban A, Martínez F. Solubility and preferential solvation of meloxicam in methanol + water mixtures at 298.15 K. J Mol Liq. 2014;197:368–373. Delgado DR, Ruidiaz MA, Gómez SM, et al. Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures. Quim Nov. 2010;33:1923–1927. |
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Taylor & Francis Group Universidad Cooperativa de Colombia, Facultad de Ingenierías, Ingeniería Civil, Neiva |
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Delgado, Daniel RicardoOrtiz, ClaudiaCardenas, RossemberCaviedes-Rubio, Diego IvanPolania-Orozco, Sebastian De JesusDelgado, Daniel Ricardo602022-10-06T17:16:41Z2022-10-06T17:16:41Z2024-02-012021-02-261029045110.1080/00319104.2021.1888382https://hdl.handle.net/20.500.12494/46633Thermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures CP Ortíz, RE Cardenas-Torres, DI Caviedes-Rubio, SDJ Polania-Orozco, ... Physics and Chemistry of Liquids 60 (1), 9-24Se presenta el análisis termodinámico y la solvación preferencial de la solubilidad de la sulfanilamida (SA) en cinco mezclas de cosolventes (etanol + agua; 1,4-dioxano + agua, acetonitrilo + agua, dimetil-sulfuróxido + agua y dimetilsulfóxido + agua). Las funciones termodinámicas se calculan empleando las ecuaciones de Gibbs y van ́t Hoff, y el análisis de la solvación preferencial se desarrolla mediante el método inverso de las integrales Kirkwood-Buff. El proceso de solubilidad es endotérmico, con favores entrópicos en todos los casos. Finalmente, de acuerdo con el parámetro de solvación, el SA se solva preferentemente con agua en mezclas más polares, y en las mezclas DMF + W y DMSO + W se solva con disolvente orgánico. En las otras mezclas (EtOH + W, DIOX + W y MeCN + W) el SA se solva por el disolvente orgánico en mezclas intermedias y por el agua en las mezclas menos polares.The thermodynamic analysis and preferential solvation of the solubility of sulphanilamide (SA) in five cosolvent mixtures (ethanol + water; 1,4-dioxane + water, acetonitrile + water, dimethyl-sulphoxide + water, and dimethylsulphoxide + water) are presented. The thermodynamic functions are calculated employing the Gibbs and van´t Hoff equations, and the analysis of preferential solvation is developed by inverse Kirkwood–Buff integrals method. The solubility process is endothermic, with entropic favouring in all cases. Finally, according to the solvation parameter, SA is solvated preferentially by water in more polar mixtures, and in DMF + W, and DMSO + W mixtures it is solvated by organic solvent. In the other mixtures (EtOH + W, DIOX + W, and MeCN + W) the SA is solvated by the organic solvent in intermediate mixtures and by water in the less polar mixtures.Introducción, Métodos, Resultados, Conclusiones, Bibliografíahttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001402116https://orcid.org/0000-0002-4835-9739https://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000004151danielr.delgado@campusucc.edu.cohttps://scholar.google.com/citations?hl=es&user=OW0mejcAAAAJ&view_op=list_works&sortby=pubdate9-24Taylor & Francis GroupUniversidad Cooperativa de Colombia, Facultad de Ingenierías, Ingeniería Civil, NeivaIngeniería CivilNeivahttps://www.tandfonline.com/doi/abs/10.1080/00319104.2021.1888382Physics and Chemistry of LiquidsPaulechka E, Kazakov A. ENTHALPY OF FORMATION OF AQUEOUS HYDROFLUORIC ACID: REVISION NEEDED? The Journal of Chemical Thermodynamics. 2020;142:106308.Du J, Xiao G, Xi Y, et al. Periodate activation with manganese oxides for sulfanilamide degradation. Water Res. 2020;169:115278.Blanco-Márquez JH, Quigua-Medina YA, García-Murillo JD, et al. Thermodynamic analysis and applications of the Abraham solvation parameter model in the study of the solubility of some sulfonamides. Rev Colomb Cienc Quím Farm. 2020;49(1):234–255.Delgado DR, Caviedes-Rubio DI, Ortiz CP, et al. Solubility of sulphadiazine in (acetonitrile + water) mixtures: measurement, correlation, thermodynamics and preferential solvation. Phys Chem Liq. 2020;58(3):381–396.Delgado DR, Martínez F. Solubility and preferential solvation of sulfadiazine in methanol+water mixtures at several temperatures. Fluid Phase Equilib. 2014;379:128–138.Blanco-Márquez JH, Caviedes Rubio DI, Ortiz CP, et al. Thermodynamic analysis and preferential solvation of sulfamethazine in acetonitrile + water cosolvent mixtures. Fluid Phase Equilib. 2020;505:112361.Blanco-Márquez JH, Ortiz CP, Cerquera NE, et al. Thermodynamic analysis of the solubility and preferential solvation of sulfamerazine in (acetonitrile + water) cosolvent mixtures at different temperatures. Journal of Molecular Liquids. 2019;293:111507.Delgado DR, Peña MA, Martínez F, et al. Further numerical analyses on the solubility of sulfapyridine in ethanol + water mixtures. Pharmaceutical Sciences. 2016;22(3):143–152.Delgado DR, Almanza OA, Martínez F, et al. Solution thermodynamics and preferential solvation of sulfamethazine in (methanol + water) mixtures. The Journal of Chemical Thermodynamics. 2016;97:264–276.Jiménez DM, Cárdenas ZJ, Delgado DR, et al. Solubility temperature dependence and preferential solvation of sulfadiazine in 1,4-dioxane+water co-solvent mixtures. Fluid Phase Equilib. 2015;397:26–36.Delgado DR, Martínez F. Preferential solvation of some structurally related sulfonamides in 1-propanol + water co-solvent mixtures. Physics and Chemistry of Liquids. 2015;53(3):293–306.Del Mar Muñoz M, Delgado DR, Peña MÁ, et al. Solubility and preferential solvation of sulfadiazine, sulfamerazine and sulfamethazine in propylene glycol+water mixtures at 298.15K. Journal of Molecular Liquids. 2015;204:132–136.Delgado DR, Martínez F. Solution thermodynamics and preferential solvation of sulfamerazine in methanol + water mixtures. J Solut Chem. 2015;44:360–377.Delgado DR, Rodríguez GA, Martínez F. Thermodynamic study of the solubility of sulfapyridine in some ethanol + water mixtures. J Mol Liq. 2013;177:156–161.Delgado DR, Peña MÁ, Martínez F. Preferential solvation of some sulfonamides in 1,4-dioxane + water co-solvent mixtures at 298.15 K according to the inverse Kirkwood-Buff integrals method. Rev Acad. Colomb. Cienc. Exact. Fis. Nat. Vol. 38. 2014. p. 104–114.Delgado DR, Jouyban A, Martínez F. Solubility and preferential solvation of meloxicam in methanol + water mixtures at 298.15 K. J Mol Liq. 2014;197:368–373.Romero-Nieto AM, Caviedes-Rubio DI, Polania-Orozco J, et al. Temperature and cosolvent composition effects in the solubility of methylparaben in acetonitrile + water mixtures. Phys Chem Liq. 2019. DOI:10.1080/ 00319104.2019.1636379Delgado DR, Jouyban A, Martínez F. Solubility and preferential solvation of meloxicam in methanol + water mixtures at 298.15 K. J Mol Liq. 2014;197:368–373.Delgado DR, Ruidiaz MA, Gómez SM, et al. Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures. Quim Nov. 2010;33:1923–1927.SulfanilamidaTermodinámica de solucionesKirkwood–BuffSolvatación PreferencialQ2Sulphanilamidesolubilityt hermodynamicKirkwood–Buffpreferential solvationThermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixturesArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionAtribución – No comercial – Compartir igualinfo:eu-repo/semantics/embargoedAccesshttp://purl.org/coar/access_right/c_f1cfPublicationORIGINALThermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures.pdfThermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures.pdfArticuloapplication/pdf5032832https://repository.ucc.edu.co/bitstreams/a839b64a-7639-4f40-a269-5b239ba0d28e/download4dc8cd0a6feb427ebf8974605cee8d49MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repository.ucc.edu.co/bitstreams/304ec98f-3087-45a7-ae8d-9432500cfe11/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILThermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures.pdf.jpgThermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures.pdf.jpgGenerated Thumbnailimage/jpeg4334https://repository.ucc.edu.co/bitstreams/2d54670c-65a0-4227-b84c-2bd8395cfcd6/download42b925b5c0dd657bab1257f7adea0abeMD53TEXTThermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures.pdf.txtThermodynamic analysis and preferential solvation of sulfanilamide in different cosolvent mixtures.pdf.txtExtracted texttext/plain45335https://repository.ucc.edu.co/bitstreams/a2727aba-2211-4643-8025-d3990405e568/downloadd878bb0988afbff34fb3b9b7749ee0dbMD5420.500.12494/46633oai:repository.ucc.edu.co:20.500.12494/466332024-08-20 16:18:19.829open.accesshttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.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 |